A mechanistic design principle for protein tyrosine kinase sensors: Application to a validated cancer target

Aya Wakata, Sean M. Cahill, Michael Blumenstein, Rosalind H. Gunby, Steffen Jockusch, Angel A. Marti, Barbara Cimbro, Carlo Gambacorti-Passerini, Arianna Donella-Deana, Lorenzo A. Pinna, Nicholas J. Turro, David S. Lawrence

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

(Graph Presented) A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalOrganic Letters
Volume10
Issue number2
DOIs
StatePublished - Jan 17 2008

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Phosphorylation
tyrosine
Protein-Tyrosine Kinases
Tyrosine
cancer
proteins
phosphorylation
sensors
Sensors
Neoplasms
acquisition
anaplastic lymphoma kinase

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Wakata, A., Cahill, S. M., Blumenstein, M., Gunby, R. H., Jockusch, S., Marti, A. A., ... Lawrence, D. S. (2008). A mechanistic design principle for protein tyrosine kinase sensors: Application to a validated cancer target. Organic Letters, 10(2), 301-304. https://doi.org/10.1021/ol702675b

A mechanistic design principle for protein tyrosine kinase sensors : Application to a validated cancer target. / Wakata, Aya; Cahill, Sean M.; Blumenstein, Michael; Gunby, Rosalind H.; Jockusch, Steffen; Marti, Angel A.; Cimbro, Barbara; Gambacorti-Passerini, Carlo; Donella-Deana, Arianna; Pinna, Lorenzo A.; Turro, Nicholas J.; Lawrence, David S.

In: Organic Letters, Vol. 10, No. 2, 17.01.2008, p. 301-304.

Research output: Contribution to journalArticle

Wakata, A, Cahill, SM, Blumenstein, M, Gunby, RH, Jockusch, S, Marti, AA, Cimbro, B, Gambacorti-Passerini, C, Donella-Deana, A, Pinna, LA, Turro, NJ & Lawrence, DS 2008, 'A mechanistic design principle for protein tyrosine kinase sensors: Application to a validated cancer target', Organic Letters, vol. 10, no. 2, pp. 301-304. https://doi.org/10.1021/ol702675b
Wakata, Aya ; Cahill, Sean M. ; Blumenstein, Michael ; Gunby, Rosalind H. ; Jockusch, Steffen ; Marti, Angel A. ; Cimbro, Barbara ; Gambacorti-Passerini, Carlo ; Donella-Deana, Arianna ; Pinna, Lorenzo A. ; Turro, Nicholas J. ; Lawrence, David S. / A mechanistic design principle for protein tyrosine kinase sensors : Application to a validated cancer target. In: Organic Letters. 2008 ; Vol. 10, No. 2. pp. 301-304.
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