A mechanistic design principle for protein tyrosine kinase sensors: Application to a validated cancer target

Aya Wakata, Sean M. Cahill, Michael Blumenstein, Rosalind H. Gunby, Steffen Jockusch, Angel A. Marti, Barbara Cimbro, Carlo Gambacorti-Passerini, Arianna Donella-Deana, Lorenzo A. Pinna, Nicholas J. Turro, David S. Lawrence

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

(Graph Presented) A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalOrganic Letters
Volume10
Issue number2
DOIs
Publication statusPublished - Jan 17 2008

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Wakata, A., Cahill, S. M., Blumenstein, M., Gunby, R. H., Jockusch, S., Marti, A. A., ... Lawrence, D. S. (2008). A mechanistic design principle for protein tyrosine kinase sensors: Application to a validated cancer target. Organic Letters, 10(2), 301-304. https://doi.org/10.1021/ol702675b