A marked potentiating effect in man of combined pancuronium and metocurine or pancuronium and d-tubocurarine neuromuscular blockade

P. W. Lebowitz; F. M. Ramsey; J. J. Savarese; H. H. Ali

A marked potentiating effect in man of combined pancuronium and metocurine or pancuronium and d-tubocurarine neuromuscular blockade

P. W. Lebowitz, F. M. Ramsey, J. J. Savarese, H. H. Ali

Anesthesiology

Research output: Contribution to journal › Article › peer-review

Abstract

Comparison of ED95 values may be made in terms of relaxant-equivalents, i.e., 1 relaxant-equivalent = .005 mg/kg of pancuronium = .02 mg/kg of metocurine = .03 mg/kg of dTc. Isobolograms constructed from this data indicate that pancuronium-metocurine and pancuronium-dTc both displayed greater than additive neuromuscular blocking potency. This marked potentiation was not seen with the metocurine-dTc combination.

Original language	English (US)
Pages (from-to)	S283
Journal	Anesthesiology
Volume	51
Issue number	3 SUPPL
State	Published - Jan 1 1979

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Cite this

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title = "A marked potentiating effect in man of combined pancuronium and metocurine or pancuronium and d-tubocurarine neuromuscular blockade",

abstract = "Comparison of ED95 values may be made in terms of relaxant-equivalents, i.e., 1 relaxant-equivalent = .005 mg/kg of pancuronium = .02 mg/kg of metocurine = .03 mg/kg of dTc. Isobolograms constructed from this data indicate that pancuronium-metocurine and pancuronium-dTc both displayed greater than additive neuromuscular blocking potency. This marked potentiation was not seen with the metocurine-dTc combination.",

author = "Lebowitz, {P. W.} and Ramsey, {F. M.} and Savarese, {J. J.} and Ali, {H. H.}",

year = "1979",

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T1 - A marked potentiating effect in man of combined pancuronium and metocurine or pancuronium and d-tubocurarine neuromuscular blockade

AU - Lebowitz, P. W.

AU - Ramsey, F. M.

AU - Savarese, J. J.

AU - Ali, H. H.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Comparison of ED95 values may be made in terms of relaxant-equivalents, i.e., 1 relaxant-equivalent = .005 mg/kg of pancuronium = .02 mg/kg of metocurine = .03 mg/kg of dTc. Isobolograms constructed from this data indicate that pancuronium-metocurine and pancuronium-dTc both displayed greater than additive neuromuscular blocking potency. This marked potentiation was not seen with the metocurine-dTc combination.

AB - Comparison of ED95 values may be made in terms of relaxant-equivalents, i.e., 1 relaxant-equivalent = .005 mg/kg of pancuronium = .02 mg/kg of metocurine = .03 mg/kg of dTc. Isobolograms constructed from this data indicate that pancuronium-metocurine and pancuronium-dTc both displayed greater than additive neuromuscular blocking potency. This marked potentiation was not seen with the metocurine-dTc combination.

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AN - SCOPUS:0018667462

SN - 0003-3022

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JO - Anesthesiology

JF - Anesthesiology

IS - 3 SUPPL

ER -

A marked potentiating effect in man of combined pancuronium and metocurine or pancuronium and d-tubocurarine neuromuscular blockade

Abstract

ASJC Scopus subject areas

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