A marked potentiating effect in man of combined pancuronium and metocurine or pancuronium and d-tubocurarine neuromuscular blockade

P. W. Lebowitz, F. M. Ramsey, J. J. Savarese, H. H. Ali

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Abstract

Comparison of ED95 values may be made in terms of relaxant-equivalents, i.e., 1 relaxant-equivalent = .005 mg/kg of pancuronium = .02 mg/kg of metocurine = .03 mg/kg of dTc. Isobolograms constructed from this data indicate that pancuronium-metocurine and pancuronium-dTc both displayed greater than additive neuromuscular blocking potency. This marked potentiation was not seen with the metocurine-dTc combination.

Original languageEnglish (US)
Pages (from-to)S283
JournalAnesthesiology
Volume51
Issue number3 SUPPL
Publication statusPublished - Jan 1 1979

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ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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