A link between relative hypoglycemia-hypoinsulinemia during oral glucose tolerance tests and intrauterine growth retardation

O. Langer, K. Damus, M. Maiman, M. Divon, Judith E. Levy, W. Bauman

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Early identification of the intrauterine growth-retarded fetus is a key factor in improving associated perinatal morbidity and mortality. We investigated, in a prospective study of 43 patients at high risk of intrauterine growth retardation, the predictive value of a derived glucose index and whether hypoglycemia accompanied by hypoinsulinemia in normotensive patients is associated with intrauterine growth retardation. Our findings suggest that the glucose index and 2-hour plasma glucose concentration appear to be useful antepartum predictors of intrauterine growth retardation in normotensive high-risk pregnancies. There is an apparent link between selective maternal hypoglycemia, hypoinsulinemia, and being small for gestational age. A 'flat' glucose tolerance test should be regarded as an abnomal pattern in normotensive pregnancies as it was associated with a twentyfold increased risk of intrauterine growth retardation in this study.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume155
Issue number4
StatePublished - 1986

Fingerprint

Fetal Growth Retardation
Glucose Tolerance Test
Hypoglycemia
Glucose
High-Risk Pregnancy
Perinatal Mortality
Gestational Age
Fetus
Mothers
Prospective Studies
Morbidity
Pregnancy
Growth

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

A link between relative hypoglycemia-hypoinsulinemia during oral glucose tolerance tests and intrauterine growth retardation. / Langer, O.; Damus, K.; Maiman, M.; Divon, M.; Levy, Judith E.; Bauman, W.

In: American Journal of Obstetrics and Gynecology, Vol. 155, No. 4, 1986, p. 711-716.

Research output: Contribution to journalArticle

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