A link between relative hypoglycemia-hypoinsulinemia during oral glucose tolerance tests and intrauterine growth retardation

Oded Langer, Karla Damus, Mitchell Maiman, Michael Divon, Judith Levy, William Bauman

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40 Scopus citations


Early identification of the intrauterine growth-retarded fetus is a key factor in improving associated perinatal morbidity and mortality. We investigated, in a prospective study of 43 patients at high risk of intrauterine growth retardation, the predictive value of a derived glucose index and whether hypoglycemia accompanied by hypoinsulinemia in normotensive patients is associated with intrauterine growth retardation. Our findings suggest that the glucose index and 2-hour plasma glucose concentration appear to be useful antepartum predictors of intrauterine growth retardation in normotensive high-risk pregnancies. There is an apparent link between selective maternal hypoglycemia, hypoinsulinemia, and being small for gestational age. A “flat” glucose tolerance test should be regarded as an abnormal pattern in normotensive pregnancies as it was associated with a twentyfold increased risk of intrauterine growth retardation in this study.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4
Publication statusPublished - Jan 1 1986



  • Hypoglycemia
  • glucose index
  • hypoinsulinemia
  • intrauterine growth retardation
  • oral glucose tolerance tests

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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