A lineage of myeloid cells independent of myb and hematopoietic stem cells

Christian Schulz, Elisa Gomez Perdiguero, Laurent Chorro, Heather Szabo-Rogers, Nicolas Cagnard, Katrin Kierdorf, Marco Prinz, Bishan Wu, Sten Eirik W Jacobsen, Jeffrey W. Pollard, Jon Frampton, Karen J. Liu, Frederic Geissmann

Research output: Contribution to journalArticle

1190 Citations (Scopus)

Abstract

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80bright macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia - cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalScience
Volume335
Issue number6077
DOIs
StatePublished - Apr 6 2012
Externally publishedYes

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Myeloid Cells
Hematopoietic Stem Cells
Macrophages
Yolk Sac
Kupffer Cells
Langerhans Cells
Microglia
Cellular Structures
Cellular Immunity
Dendritic Cells
Monocytes
Transcription Factors
Embryonic Structures
Liver
Population

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., ... Geissmann, F. (2012). A lineage of myeloid cells independent of myb and hematopoietic stem cells. Science, 335(6077), 86-90. https://doi.org/10.1126/science.1219179

A lineage of myeloid cells independent of myb and hematopoietic stem cells. / Schulz, Christian; Perdiguero, Elisa Gomez; Chorro, Laurent; Szabo-Rogers, Heather; Cagnard, Nicolas; Kierdorf, Katrin; Prinz, Marco; Wu, Bishan; Jacobsen, Sten Eirik W; Pollard, Jeffrey W.; Frampton, Jon; Liu, Karen J.; Geissmann, Frederic.

In: Science, Vol. 335, No. 6077, 06.04.2012, p. 86-90.

Research output: Contribution to journalArticle

Schulz, C, Perdiguero, EG, Chorro, L, Szabo-Rogers, H, Cagnard, N, Kierdorf, K, Prinz, M, Wu, B, Jacobsen, SEW, Pollard, JW, Frampton, J, Liu, KJ & Geissmann, F 2012, 'A lineage of myeloid cells independent of myb and hematopoietic stem cells', Science, vol. 335, no. 6077, pp. 86-90. https://doi.org/10.1126/science.1219179
Schulz C, Perdiguero EG, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K et al. A lineage of myeloid cells independent of myb and hematopoietic stem cells. Science. 2012 Apr 6;335(6077):86-90. https://doi.org/10.1126/science.1219179
Schulz, Christian ; Perdiguero, Elisa Gomez ; Chorro, Laurent ; Szabo-Rogers, Heather ; Cagnard, Nicolas ; Kierdorf, Katrin ; Prinz, Marco ; Wu, Bishan ; Jacobsen, Sten Eirik W ; Pollard, Jeffrey W. ; Frampton, Jon ; Liu, Karen J. ; Geissmann, Frederic. / A lineage of myeloid cells independent of myb and hematopoietic stem cells. In: Science. 2012 ; Vol. 335, No. 6077. pp. 86-90.
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