Abstract
The deposition of tau inclusions is one of the neuropathological hallmarks in neurodegenerative disorders with dementia. We have reported that the N-terminal fragment of a human granin-like neuroendocrine peptide precursor (N-proSAAS) is accumulated in Pick bodies. However, it is unknown whether N-proSAAS is widely accumulated in tau inclusions in other tauopathies. Here, we performed an immunohistochemical examination using antibodies against both the N- and C-terminal sequence of proSAAS in the brains of patients with Alzheimer's disease and parkinsonism-dementia complex on Guam. The antibody against N-proSAAS immunostained neurofibrillary tangles and neuritic plaques in both diseases, whereas the antibody against the C-terminal sequence of proSAAS did not. The results of the present study suggest that N-proSAAS or proSAAS-like molecules were trapped within the tau fibrils and accumulated in tau inclusions.
Original language | English (US) |
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Pages (from-to) | 49-52 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 356 |
Issue number | 1 |
DOIs | |
State | Published - Feb 6 2004 |
Keywords
- Alzheimer's disease
- Immunohistochemistry
- Neurofibrillary tangle
- Parkinsonism- dementia complex
- Tau
- proSAAS
ASJC Scopus subject areas
- General Neuroscience