A human adult Wilms' tumor. Histologic, ultrastructural, and cytogenetic analysis

Judith B. Sherwood, Richard Bard, Meenakshi Bhargava, Edward R. Burns, Mohammed A. Iqbal

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The cytogenetic, histologic, and electron microscopic studies of an adult patient with Wilms' tumor are presented. Wilms' tumor (nephroblastoma) is a common renal tumor of childhood but is extremely rare in people over 15 years old. The histologic analysis of the patient's tumor, including both light and electron microscopic analysis, indicated that this tumor satisfies the histologic criteria for an adult Wilms' tumor, namely, blastemic cells that are immature renal parenchymal cells, embryonic tubular structures, and a scanty stromal component consisting of loosely arranged spindle cells. The tumor showed several ultrastructural features characteristic of adult Wilms' tumor, namely, markedly elongated mitochondria, autophagic vacuoles, and intracytoplasmic filaments. Karyotypic analysis was performed on the patient's peripheral leukocytes and tumor cells. The leukocytes showed no significant increase in gaps and breaks, and the patient appears to have a normal male karyotype. Some interesting chromosomal anomalies were observed in the cultured tumor cells: at least one chromosome 13, both chromosomes 22, and the X chromosome are missing, three markers are present, and there is a possible deletion of 12p.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume42
Issue number1
DOIs
StatePublished - Oct 1 1989

Fingerprint

Wilms Tumor
Cytogenetic Analysis
Neoplasms
Leukocytes
Electrons
Cultured Tumor Cells
Kidney
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 13
X Chromosome
Vacuoles
Karyotype
Cytogenetics
Mitochondria
Embryonic Structures
Light

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

A human adult Wilms' tumor. Histologic, ultrastructural, and cytogenetic analysis. / Sherwood, Judith B.; Bard, Richard; Bhargava, Meenakshi; Burns, Edward R.; Iqbal, Mohammed A.

In: Cancer Genetics and Cytogenetics, Vol. 42, No. 1, 01.10.1989, p. 35-42.

Research output: Contribution to journalArticle

Sherwood, Judith B. ; Bard, Richard ; Bhargava, Meenakshi ; Burns, Edward R. ; Iqbal, Mohammed A. / A human adult Wilms' tumor. Histologic, ultrastructural, and cytogenetic analysis. In: Cancer Genetics and Cytogenetics. 1989 ; Vol. 42, No. 1. pp. 35-42.
@article{a5033e1c838d450eb3ae40af76391bc8,
title = "A human adult Wilms' tumor. Histologic, ultrastructural, and cytogenetic analysis",
abstract = "The cytogenetic, histologic, and electron microscopic studies of an adult patient with Wilms' tumor are presented. Wilms' tumor (nephroblastoma) is a common renal tumor of childhood but is extremely rare in people over 15 years old. The histologic analysis of the patient's tumor, including both light and electron microscopic analysis, indicated that this tumor satisfies the histologic criteria for an adult Wilms' tumor, namely, blastemic cells that are immature renal parenchymal cells, embryonic tubular structures, and a scanty stromal component consisting of loosely arranged spindle cells. The tumor showed several ultrastructural features characteristic of adult Wilms' tumor, namely, markedly elongated mitochondria, autophagic vacuoles, and intracytoplasmic filaments. Karyotypic analysis was performed on the patient's peripheral leukocytes and tumor cells. The leukocytes showed no significant increase in gaps and breaks, and the patient appears to have a normal male karyotype. Some interesting chromosomal anomalies were observed in the cultured tumor cells: at least one chromosome 13, both chromosomes 22, and the X chromosome are missing, three markers are present, and there is a possible deletion of 12p.",
author = "Sherwood, {Judith B.} and Richard Bard and Meenakshi Bhargava and Burns, {Edward R.} and Iqbal, {Mohammed A.}",
year = "1989",
month = "10",
day = "1",
doi = "10.1016/0165-4608(89)90005-8",
language = "English (US)",
volume = "42",
pages = "35--42",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - A human adult Wilms' tumor. Histologic, ultrastructural, and cytogenetic analysis

AU - Sherwood, Judith B.

AU - Bard, Richard

AU - Bhargava, Meenakshi

AU - Burns, Edward R.

AU - Iqbal, Mohammed A.

PY - 1989/10/1

Y1 - 1989/10/1

N2 - The cytogenetic, histologic, and electron microscopic studies of an adult patient with Wilms' tumor are presented. Wilms' tumor (nephroblastoma) is a common renal tumor of childhood but is extremely rare in people over 15 years old. The histologic analysis of the patient's tumor, including both light and electron microscopic analysis, indicated that this tumor satisfies the histologic criteria for an adult Wilms' tumor, namely, blastemic cells that are immature renal parenchymal cells, embryonic tubular structures, and a scanty stromal component consisting of loosely arranged spindle cells. The tumor showed several ultrastructural features characteristic of adult Wilms' tumor, namely, markedly elongated mitochondria, autophagic vacuoles, and intracytoplasmic filaments. Karyotypic analysis was performed on the patient's peripheral leukocytes and tumor cells. The leukocytes showed no significant increase in gaps and breaks, and the patient appears to have a normal male karyotype. Some interesting chromosomal anomalies were observed in the cultured tumor cells: at least one chromosome 13, both chromosomes 22, and the X chromosome are missing, three markers are present, and there is a possible deletion of 12p.

AB - The cytogenetic, histologic, and electron microscopic studies of an adult patient with Wilms' tumor are presented. Wilms' tumor (nephroblastoma) is a common renal tumor of childhood but is extremely rare in people over 15 years old. The histologic analysis of the patient's tumor, including both light and electron microscopic analysis, indicated that this tumor satisfies the histologic criteria for an adult Wilms' tumor, namely, blastemic cells that are immature renal parenchymal cells, embryonic tubular structures, and a scanty stromal component consisting of loosely arranged spindle cells. The tumor showed several ultrastructural features characteristic of adult Wilms' tumor, namely, markedly elongated mitochondria, autophagic vacuoles, and intracytoplasmic filaments. Karyotypic analysis was performed on the patient's peripheral leukocytes and tumor cells. The leukocytes showed no significant increase in gaps and breaks, and the patient appears to have a normal male karyotype. Some interesting chromosomal anomalies were observed in the cultured tumor cells: at least one chromosome 13, both chromosomes 22, and the X chromosome are missing, three markers are present, and there is a possible deletion of 12p.

UR - http://www.scopus.com/inward/record.url?scp=0024458411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024458411&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(89)90005-8

DO - 10.1016/0165-4608(89)90005-8

M3 - Article

C2 - 2551484

AN - SCOPUS:0024458411

VL - 42

SP - 35

EP - 42

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -