A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis

Livia Cristina Liporagi Lopes, Allan J. Guimarães, Mariana Duarte De Cerqueira, Beatriz L. Gómez, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

Original languageEnglish (US)
Pages (from-to)1155-1158
Number of pages4
JournalClinical and Vaccine Immunology
Volume17
Issue number7
DOIs
StatePublished - 2010

Fingerprint

Histoplasma
Histoplasmosis
Membrane Proteins
Immunoglobulin G
Monoclonal Antibodies
Host-Pathogen Interactions
Macrophages
Pathogens
Nitric Oxide
Antigens
Growth
Infection

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)
  • Medicine(all)

Cite this

A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis. / Lopes, Livia Cristina Liporagi; Guimarães, Allan J.; De Cerqueira, Mariana Duarte; Gómez, Beatriz L.; Nosanchuk, Joshua D.

In: Clinical and Vaccine Immunology, Vol. 17, No. 7, 2010, p. 1155-1158.

Research output: Contribution to journalArticle

Lopes, Livia Cristina Liporagi ; Guimarães, Allan J. ; De Cerqueira, Mariana Duarte ; Gómez, Beatriz L. ; Nosanchuk, Joshua D. / A histoplasma capsulatum-specific IgG1 isotype monoclonal antibody, H1C, to a 70-kilodalton cell surface protein is not protective in murine histoplasmosis. In: Clinical and Vaccine Immunology. 2010 ; Vol. 17, No. 7. pp. 1155-1158.
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