A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice

Michael Kruse, Ariana Fiallo, Jianling Tao, Maureen J. Charron, Kerstin Amann, Ellen B. Katz, Maureen J. Charron

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aims: Altered nutrients during the in utero (IU) and/or lactation (L) period predispose offspring to cardio-renal diseases in adulthood. This study investigates the effect of a high fat diet (HFD) fed to female mice during IU/L on gene expression patterns associated with heart and kidney failure and hypertension in male offspring. Methods: Female wild type (WT) mice were fed either a HFD or control chow (C) prior to mating with males with a genetic heterozygous deletion of GLUT4 (G4+/-, a model of peripheral insulin resistance and hypertension) and throughout IU/L. After weaning male offspring were placed on a standard rodent chow until 24 weeks of age. Results: All offspring exposed to a maternal HFD showed increased heart and kidney weight and reduced cardiac insulin responsiveness. G4+/- offspring on a HFD displayed early hypertension associated with increased renal gene expression of renin and the AT1- receptors compared to G4+/- on a C diet. This group showed decreased cardiac expression of key genes involved in fatty acid oxidation compared to WT on a C diet. Conclusions: These results indicate an interaction between a HFD diet and genotype during early life development that can enhance susceptibility to cardio-renal diseases later in life.

Original languageEnglish (US)
Pages (from-to)468-482
Number of pages15
JournalKidney and Blood Pressure Research
DOIs
StateAccepted/In press - Jul 27 2017

Fingerprint

High Fat Diet
Lactation
Kidney
Pregnancy
Diet
Hypertension
Gene Expression
Weaning
Renin
Vascular Resistance
Renal Insufficiency
Insulin Resistance
Rodentia
Fatty Acids
Heart Failure
Genotype
Mothers
Insulin
Weights and Measures
Food

Keywords

  • Cardiorenal Syndrome
  • Fetal Programming
  • GLUT4
  • High Fat Diet
  • Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nephrology

Cite this

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice. / Kruse, Michael; Fiallo, Ariana; Tao, Jianling; Charron, Maureen J.; Amann, Kerstin; Katz, Ellen B.; Charron, Maureen J.

In: Kidney and Blood Pressure Research, 27.07.2017, p. 468-482.

Research output: Contribution to journalArticle

Kruse, Michael ; Fiallo, Ariana ; Tao, Jianling ; Charron, Maureen J. ; Amann, Kerstin ; Katz, Ellen B. ; Charron, Maureen J. / A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice. In: Kidney and Blood Pressure Research. 2017 ; pp. 468-482.
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