A healthy lifestyle index and its association with risk of breast, endometrial, and ovarian cancer among Canadian women

Rhonda Arthur, Victoria A. Kirsh, Nancy Kreiger, Thomas E. Rohan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Several modifiable risk factors have been associated with risk of female cancers, but there is limited data regarding their combined effect on risk among Canadian women. Therefore, we assessed the joint association of modifiable risk factors, using a healthy lifestyle index (HLI) score, with risk of specific reproductive cancers. Method: This study included a subcohort of 3,185 of the 39,618 women, who participated in the Canadian Study of Diet, Lifestyle, and Health, and in whom 410, 177, and 100 postmenopausal breast, endometrial, and ovarian cancers, respectively, were ascertained. We estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards regression models modified for the case-cohort design. Results: Each unit increase in the HLI score was associated with 3% and 5% reductions in risk of postmenopausal breast cancer and endometrial cancer, respectively (HR 0.97; 95% CI 0.94–0.99 and HR 0.95; 95% CI 0.90–0.99, respectively). Compared to those with HLI score in the lowest category, those in the highest category had 30% and 46% reductions in risk of these cancers, respectively. The HLI score was not associated with altered risk of ovarian cancer. Conclusion: Our findings suggest that promoting a healthy lifestyle may aid in the primary prevention of postmenopausal breast and endometrial cancers.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCancer Causes and Control
DOIs
StateAccepted/In press - Apr 17 2018

Fingerprint

Endometrial Neoplasms
Ovarian Neoplasms
Breast Neoplasms
Confidence Intervals
Risk Reduction Behavior
Neoplasms
Primary Prevention
Proportional Hazards Models
Life Style
Healthy Lifestyle
Diet
Health

Keywords

  • Breast cancer
  • Endometrial cancer
  • Healthy lifestyle index score
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A healthy lifestyle index and its association with risk of breast, endometrial, and ovarian cancer among Canadian women. / Arthur, Rhonda; Kirsh, Victoria A.; Kreiger, Nancy; Rohan, Thomas E.

In: Cancer Causes and Control, 17.04.2018, p. 1-9.

Research output: Contribution to journalArticle

@article{053bab8532f34a79b8c2a5f030a0c3d3,
title = "A healthy lifestyle index and its association with risk of breast, endometrial, and ovarian cancer among Canadian women",
abstract = "Purpose: Several modifiable risk factors have been associated with risk of female cancers, but there is limited data regarding their combined effect on risk among Canadian women. Therefore, we assessed the joint association of modifiable risk factors, using a healthy lifestyle index (HLI) score, with risk of specific reproductive cancers. Method: This study included a subcohort of 3,185 of the 39,618 women, who participated in the Canadian Study of Diet, Lifestyle, and Health, and in whom 410, 177, and 100 postmenopausal breast, endometrial, and ovarian cancers, respectively, were ascertained. We estimated hazard ratios (HR) and 95{\%} confidence intervals (CI) using Cox proportional hazards regression models modified for the case-cohort design. Results: Each unit increase in the HLI score was associated with 3{\%} and 5{\%} reductions in risk of postmenopausal breast cancer and endometrial cancer, respectively (HR 0.97; 95{\%} CI 0.94–0.99 and HR 0.95; 95{\%} CI 0.90–0.99, respectively). Compared to those with HLI score in the lowest category, those in the highest category had 30{\%} and 46{\%} reductions in risk of these cancers, respectively. The HLI score was not associated with altered risk of ovarian cancer. Conclusion: Our findings suggest that promoting a healthy lifestyle may aid in the primary prevention of postmenopausal breast and endometrial cancers.",
keywords = "Breast cancer, Endometrial cancer, Healthy lifestyle index score, Ovarian cancer",
author = "Rhonda Arthur and Kirsh, {Victoria A.} and Nancy Kreiger and Rohan, {Thomas E.}",
year = "2018",
month = "4",
day = "17",
doi = "10.1007/s10552-018-1032-1",
language = "English (US)",
pages = "1--9",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - A healthy lifestyle index and its association with risk of breast, endometrial, and ovarian cancer among Canadian women

AU - Arthur, Rhonda

AU - Kirsh, Victoria A.

AU - Kreiger, Nancy

AU - Rohan, Thomas E.

PY - 2018/4/17

Y1 - 2018/4/17

N2 - Purpose: Several modifiable risk factors have been associated with risk of female cancers, but there is limited data regarding their combined effect on risk among Canadian women. Therefore, we assessed the joint association of modifiable risk factors, using a healthy lifestyle index (HLI) score, with risk of specific reproductive cancers. Method: This study included a subcohort of 3,185 of the 39,618 women, who participated in the Canadian Study of Diet, Lifestyle, and Health, and in whom 410, 177, and 100 postmenopausal breast, endometrial, and ovarian cancers, respectively, were ascertained. We estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards regression models modified for the case-cohort design. Results: Each unit increase in the HLI score was associated with 3% and 5% reductions in risk of postmenopausal breast cancer and endometrial cancer, respectively (HR 0.97; 95% CI 0.94–0.99 and HR 0.95; 95% CI 0.90–0.99, respectively). Compared to those with HLI score in the lowest category, those in the highest category had 30% and 46% reductions in risk of these cancers, respectively. The HLI score was not associated with altered risk of ovarian cancer. Conclusion: Our findings suggest that promoting a healthy lifestyle may aid in the primary prevention of postmenopausal breast and endometrial cancers.

AB - Purpose: Several modifiable risk factors have been associated with risk of female cancers, but there is limited data regarding their combined effect on risk among Canadian women. Therefore, we assessed the joint association of modifiable risk factors, using a healthy lifestyle index (HLI) score, with risk of specific reproductive cancers. Method: This study included a subcohort of 3,185 of the 39,618 women, who participated in the Canadian Study of Diet, Lifestyle, and Health, and in whom 410, 177, and 100 postmenopausal breast, endometrial, and ovarian cancers, respectively, were ascertained. We estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards regression models modified for the case-cohort design. Results: Each unit increase in the HLI score was associated with 3% and 5% reductions in risk of postmenopausal breast cancer and endometrial cancer, respectively (HR 0.97; 95% CI 0.94–0.99 and HR 0.95; 95% CI 0.90–0.99, respectively). Compared to those with HLI score in the lowest category, those in the highest category had 30% and 46% reductions in risk of these cancers, respectively. The HLI score was not associated with altered risk of ovarian cancer. Conclusion: Our findings suggest that promoting a healthy lifestyle may aid in the primary prevention of postmenopausal breast and endometrial cancers.

KW - Breast cancer

KW - Endometrial cancer

KW - Healthy lifestyle index score

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=85045466197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045466197&partnerID=8YFLogxK

U2 - 10.1007/s10552-018-1032-1

DO - 10.1007/s10552-018-1032-1

M3 - Article

C2 - 29667103

AN - SCOPUS:85045466197

SP - 1

EP - 9

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

ER -