A glucose transport protein expressed predominately in insulin-responsive tissues

M. J. Charron, F. C. Brosius, S. L. Alper, H. F. Lodish

Research output: Contribution to journalArticle

314 Scopus citations

Abstract

Using low-stringency hybridization to the rat brain glucose transporter (GT), a 2489-base-pair cDNA clone was isolated from a rat soleus λgt10 cDNA library. It encodes a 509-amino acid protein whose sequence and predicted membrane structure is very similar to those of the rat brain and liver GTs. The muscle GT-like protein is 65% identical in amino acid sequence to the rat brain GT and 52% identical to the rat liver GT; the major differences are in the NH2- and COOH-terminal hydrophilic segments. This GT-like mRNA is expressed predominately in tissues where glucose transport is sensitive to insulin, including striated muscle, cardiac muscle, and adipose tissue; low-level expression is also detected in smooth muscle and kidney mRNA. This GT-like cDNA is the fourth member of the mammalian GT-related gene family identified to date. We propose that it encodes an insulin-sensitive GT.

Original languageEnglish (US)
Pages (from-to)2535-2539
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number8
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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