A glucose-controlled insulin-delivery system: Semisynthetic insulin bound to lectin

Michael Brownlee, Anthony Cerami

Research output: Contribution to journalArticle

207 Scopus citations

Abstract

A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)1190-1191
Number of pages2
JournalScience
Volume206
Issue number4423
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • General

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