A glucose-controlled insulin-delivery system: Semisynthetic insulin bound to lectin

Michael Brownlee; Anthony Cerami

doi:10.1126/science.505005

A glucose-controlled insulin-delivery system: Semisynthetic insulin bound to lectin

Michael Brownlee, Anthony Cerami

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

Abstract

A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.

Original language	English (US)
Pages (from-to)	1190-1191
Number of pages	2
Journal	Science
Volume	206
Issue number	4423
DOIs	https://doi.org/10.1126/science.505005
State	Published - 1979
Externally published	Yes

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title = "A glucose-controlled insulin-delivery system: Semisynthetic insulin bound to lectin",

abstract = "A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.",

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A glucose-controlled insulin-delivery system: Semisynthetic insulin bound to lectin

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