A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Oren Kalus; Scott Wetzler; René S. Kahn; Gregory M. Asnis; Herman M. van Praag

doi:10.1007/BF02245423

A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Oren Kalus, Scott Wetzler, René S. Kahn, Gregory M. Asnis, Herman M. van Praag

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

Original language	English (US)
Pages (from-to)	388-390
Number of pages	3
Journal	Psychopharmacology
Volume	106
Issue number	3
DOIs	https://doi.org/10.1007/BF02245423
State	Published - Mar 1 1992

Keywords

Dose-response
Intravenous
MCPP
Serotonin

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1007/BF02245423

Cite this

@article{ae8e2635be3240d9a4490a8f50f49f27,

title = "A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects",

abstract = "A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.",

keywords = "Dose-response, Intravenous, MCPP, Serotonin",

author = "Oren Kalus and Scott Wetzler and Kahn, {Ren{\'e} S.} and Asnis, {Gregory M.} and {van Praag}, {Herman M.}",

year = "1992",

month = mar,

day = "1",

doi = "10.1007/BF02245423",

language = "English (US)",

volume = "106",

pages = "388--390",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

AU - Kalus, Oren

AU - Wetzler, Scott

AU - Kahn, René S.

AU - Asnis, Gregory M.

AU - van Praag, Herman M.

PY - 1992/3/1

Y1 - 1992/3/1

N2 - A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

AB - A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

KW - Dose-response

KW - Intravenous

KW - MCPP

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0026556963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026556963&partnerID=8YFLogxK

U2 - 10.1007/BF02245423

DO - 10.1007/BF02245423

M3 - Article

C2 - 1533289

AN - SCOPUS:0026556963

SN - 0033-3158

VL - 106

SP - 388

EP - 390

JO - Psychopharmacology

JF - Psychopharmacology

IS - 3

ER -

A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this