A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Oren Kalus; Scott Wetzler; René S. Kahn; Gregory M. Asnis; Herman M. van Praag

doi:10.1007/BF02245423

A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Oren Kalus, Scott Wetzler, René S. Kahn, Gregory M. Asnis, Herman M. van Praag

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

Original language	English (US)
Pages (from-to)	388-390
Number of pages	3
Journal	Psychopharmacology
Volume	106
Issue number	3
DOIs	https://doi.org/10.1007/BF02245423
State	Published - Mar 1992

Keywords

Dose-response
Intravenous
MCPP
Serotonin

ASJC Scopus subject areas

Pharmacology

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10.1007/BF02245423

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abstract = "A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.",

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AU - Wetzler, Scott

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AU - Asnis, Gregory M.

AU - van Praag, Herman M.

PY - 1992/3

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AB - A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

KW - Dose-response

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KW - MCPP

KW - Serotonin

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A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Abstract

Keywords

ASJC Scopus subject areas

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