A dose-response study of intravenous m-chlorophenylpiperazine in normal subjects

Oren Kalus, Scott Wetzler, René S. Kahn, Gregory M. Asnis, Herman M. van Praag

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A placebo-controlled dose-response study of the direct serotonin receptor agonist m-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.

Original languageEnglish (US)
Pages (from-to)388-390
Number of pages3
JournalPsychopharmacology
Volume106
Issue number3
DOIs
StatePublished - Mar 1 1992

Keywords

  • Dose-response
  • Intravenous
  • MCPP
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

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