We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.
|Original language||English (US)|
|Number of pages||3|
|Journal||British Journal of Haematology|
|State||Published - 1994|
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