A distinct coagulopathy associated with interleukin-2 therapy

L. Oleksowicz, M. Strack, J. P. Dutcher, I. Sussman, G. Caliendo, J. Sparano, P. H. Wiernik

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10 Scopus citations


We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.

Original languageEnglish (US)
Pages (from-to)892-894
Number of pages3
JournalBritish Journal of Haematology
Issue number4
StatePublished - Jan 1 1994


  • Coagulopathy
  • IL-2
  • Malignancy

ASJC Scopus subject areas

  • Hematology

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    Oleksowicz, L., Strack, M., Dutcher, J. P., Sussman, I., Caliendo, G., Sparano, J., & Wiernik, P. H. (1994). A distinct coagulopathy associated with interleukin-2 therapy. British Journal of Haematology, 88(4), 892-894. https://doi.org/10.1111/j.1365-2141.1994.tb05135.x