A distinct coagulopathy associated with interleukin-2 therapy

L. Oleksowicz; M. Strack; J. P. Dutcher; I. Sussman; G. Caliendo; J. Sparano; P. H. Wiernik

doi:10.1111/j.1365-2141.1994.tb05135.x

A distinct coagulopathy associated with interleukin-2 therapy

L. Oleksowicz, M. Strack, J. P. Dutcher, I. Sussman, G. Caliendo, J. Sparano, P. H. Wiernik

Medicine

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12 Scopus citations

Abstract

We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.

Original language	English (US)
Pages (from-to)	892-894
Number of pages	3
Journal	British Journal of Haematology
Volume	88
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.1994.tb05135.x
State	Published - 1994

Keywords

Coagulopathy
IL-2
Malignancy

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.1994.tb05135.x

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title = "A distinct coagulopathy associated with interleukin-2 therapy",

abstract = "We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.",

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T1 - A distinct coagulopathy associated with interleukin-2 therapy

AU - Oleksowicz, L.

AU - Strack, M.

AU - Dutcher, J. P.

AU - Sussman, I.

AU - Caliendo, G.

AU - Sparano, J.

AU - Wiernik, P. H.

PY - 1994

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N2 - We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.

AB - We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.

KW - Coagulopathy

KW - IL-2

KW - Malignancy

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A distinct coagulopathy associated with interleukin-2 therapy

Abstract

Keywords

ASJC Scopus subject areas

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