A distinct coagulopathy associated with interleukin-2 therapy

L. Oleksowicz, M. Strack, J. P. Dutcher, I. Sussman, G. Caliendo, Joseph A. Sparano, P. H. Wiernik

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.

Original languageEnglish (US)
Pages (from-to)892-894
Number of pages3
JournalBritish Journal of Haematology
Volume88
Issue number4
StatePublished - 1994

Fingerprint

Interleukin-2
Factor VII
Factor IX
Factor V
Prothrombin
Therapeutics
Fibrinogen
Neoplasms

Keywords

  • Coagulopathy
  • IL-2
  • Malignancy

ASJC Scopus subject areas

  • Hematology

Cite this

Oleksowicz, L., Strack, M., Dutcher, J. P., Sussman, I., Caliendo, G., Sparano, J. A., & Wiernik, P. H. (1994). A distinct coagulopathy associated with interleukin-2 therapy. British Journal of Haematology, 88(4), 892-894.

A distinct coagulopathy associated with interleukin-2 therapy. / Oleksowicz, L.; Strack, M.; Dutcher, J. P.; Sussman, I.; Caliendo, G.; Sparano, Joseph A.; Wiernik, P. H.

In: British Journal of Haematology, Vol. 88, No. 4, 1994, p. 892-894.

Research output: Contribution to journalArticle

Oleksowicz, L, Strack, M, Dutcher, JP, Sussman, I, Caliendo, G, Sparano, JA & Wiernik, PH 1994, 'A distinct coagulopathy associated with interleukin-2 therapy', British Journal of Haematology, vol. 88, no. 4, pp. 892-894.
Oleksowicz L, Strack M, Dutcher JP, Sussman I, Caliendo G, Sparano JA et al. A distinct coagulopathy associated with interleukin-2 therapy. British Journal of Haematology. 1994;88(4):892-894.
Oleksowicz, L. ; Strack, M. ; Dutcher, J. P. ; Sussman, I. ; Caliendo, G. ; Sparano, Joseph A. ; Wiernik, P. H. / A distinct coagulopathy associated with interleukin-2 therapy. In: British Journal of Haematology. 1994 ; Vol. 88, No. 4. pp. 892-894.
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