A dimensional approach to the autism spectrum

Eric Hollander; Charles Cartwright; Cheryl M. Wong; Concerta M. Decaria; Gina Delgiudice-Asch; Monte S. Buchsbaum; Bonnie R. Aronowitz

doi:10.1017/S1092852900005678

A dimensional approach to the autism spectrum

Eric Hollander, Charles Cartwright, Cheryl M. Wong, Concerta M. Decaria, Gina Delgiudice-Asch, Monte S. Buchsbaum, Bonnie R. Aronowitz

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Autism is heterogeneous with respect to clinical symptoms and etiology. A significant limitation in research of the neurobiology and treatment of autism has been the lack of attention to this heterogeneity. A dimensional approach to the study of autism is valuable in linking key symptoms to the neurobiology and treatment of the disorder in a clinically meaningful way. In this article, we outline a dimensional approach to the autism spectrum, discuss the three core dimensions of autism and their neurobiology, and review the possible links of serotonin, anterior cingulate gyrus activity, and the immune marker D8/17 to the repetitive behavior/compulsivity dimensions.

Original language	English (US)
Pages (from-to)	22-39
Number of pages	18
Journal	CNS spectrums
Volume	3
Issue number	3
DOIs	https://doi.org/10.1017/S1092852900005678
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S1092852900005678

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title = "A dimensional approach to the autism spectrum",

abstract = "Autism is heterogeneous with respect to clinical symptoms and etiology. A significant limitation in research of the neurobiology and treatment of autism has been the lack of attention to this heterogeneity. A dimensional approach to the study of autism is valuable in linking key symptoms to the neurobiology and treatment of the disorder in a clinically meaningful way. In this article, we outline a dimensional approach to the autism spectrum, discuss the three core dimensions of autism and their neurobiology, and review the possible links of serotonin, anterior cingulate gyrus activity, and the immune marker D8/17 to the repetitive behavior/compulsivity dimensions.",

author = "Eric Hollander and Charles Cartwright and Wong, {Cheryl M.} and Decaria, {Concerta M.} and Gina Delgiudice-Asch and Buchsbaum, {Monte S.} and Aronowitz, {Bonnie R.}",

year = "1998",

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language = "English (US)",

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T1 - A dimensional approach to the autism spectrum

AU - Hollander, Eric

AU - Cartwright, Charles

AU - Wong, Cheryl M.

AU - Decaria, Concerta M.

AU - Delgiudice-Asch, Gina

AU - Buchsbaum, Monte S.

AU - Aronowitz, Bonnie R.

PY - 1998

Y1 - 1998

N2 - Autism is heterogeneous with respect to clinical symptoms and etiology. A significant limitation in research of the neurobiology and treatment of autism has been the lack of attention to this heterogeneity. A dimensional approach to the study of autism is valuable in linking key symptoms to the neurobiology and treatment of the disorder in a clinically meaningful way. In this article, we outline a dimensional approach to the autism spectrum, discuss the three core dimensions of autism and their neurobiology, and review the possible links of serotonin, anterior cingulate gyrus activity, and the immune marker D8/17 to the repetitive behavior/compulsivity dimensions.

AB - Autism is heterogeneous with respect to clinical symptoms and etiology. A significant limitation in research of the neurobiology and treatment of autism has been the lack of attention to this heterogeneity. A dimensional approach to the study of autism is valuable in linking key symptoms to the neurobiology and treatment of the disorder in a clinically meaningful way. In this article, we outline a dimensional approach to the autism spectrum, discuss the three core dimensions of autism and their neurobiology, and review the possible links of serotonin, anterior cingulate gyrus activity, and the immune marker D8/17 to the repetitive behavior/compulsivity dimensions.

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DO - 10.1017/S1092852900005678

M3 - Review article

AN - SCOPUS:0032455143

SN - 1092-8529

VL - 3

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EP - 39

JO - CNS spectrums

JF - CNS spectrums

IS - 3

ER -

A dimensional approach to the autism spectrum

Abstract

ASJC Scopus subject areas

UN SDGs

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