A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye

Cheng Zhang, Laura Asnaghi, Celine Gongora, Bonnie Patek, Stacey Hose, Bo Ma, Masoud Aghsaei Fard, Lawrence Brako, Kamaljeet Singh, Morton F. Goldberg, James T. Handa, Woo Kuen Lo, Charles G. Eberhart, J. Samuel Zigler, Debasish Sinha

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Previously we reported the novel observation that astrocytes ensheath the persistent hyaloid artery, both in the Nuc1 spontaneous mutant rat, and in human PFV (persistent fetal vasculature) disease (Developmental Dynamics 234:36-47, 2005). We now show that astrocytes isolated from both the optic nerve and retina of Nuc1 rats migrate faster than wild type astrocytes. Aquaporin 4 (AQP4), the major water channel in astrocytes, has been shown to be important in astrocyte migration. We demonstrate that AQP4 expression is elevated in the astrocytes in PFV conditions, and we hypothesize that this causes the cells to migrate abnormally into the vitreous where they ensheath the hyaloid artery. This abnormal association of astrocytes with the hyaloid artery may impede the normal macrophage-mediated remodeling and regression of the hyaloid system.

Original languageEnglish (US)
Pages (from-to)440-448
Number of pages9
JournalEuropean Journal of Cell Biology
Volume90
Issue number5
DOIs
StatePublished - May 1 2011
Externally publishedYes

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Keywords

  • Aquaporin-4 (AQP4)
  • Astrocytes
  • Hyaloid vascular system
  • Migration
  • Optic nerve and retina
  • βA3/A1-crystallin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Zhang, C., Asnaghi, L., Gongora, C., Patek, B., Hose, S., Ma, B., Fard, M. A., Brako, L., Singh, K., Goldberg, M. F., Handa, J. T., Lo, W. K., Eberhart, C. G., Zigler, J. S., & Sinha, D. (2011). A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye. European Journal of Cell Biology, 90(5), 440-448. https://doi.org/10.1016/j.ejcb.2011.01.003