A decade of DTI in traumatic brain injury: 10 years and 100 articles later

M. B. Hulkower, D. B. Poliak, S. B. Rosenbaum, M. E. Zimmerman, Michael L. Lipton

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

The past decade has seen an increase in the number of articles reporting the use of DTI to detect brain abnormalities in patients with traumatic brain injury. DTI is well-suited to the interrogation of white matter microstructure, the most important location of pathology in TBI. Additionally, studies in animal models have demonstrated the correlation of DTI findings and TBI pathology. One hundred articles met the inclusion criteria for this quantitative literature review. Despite significant variability in sample characteristics, technical aspects of imaging, and analysis approaches, the consensus is that DTI effectively differentiates patients with TBI and controls, regardless of the severity and timeframe following injury. Furthermore, many have established a relationship between DTI measures and TBI outcomes. However, the heterogeneity of specific outcome measures used limits interpretation of the literature. Similarly, few longitudinal studies have been performed, limiting inferences regarding the long-term predictive utility of DTI. Larger longitudinal studies, using standardized imaging, analysis approaches, and outcome measures will help realize the promise of DTI as a prognostic tool in the care of patients with TBI.

Original languageEnglish (US)
Pages (from-to)2064-2074
Number of pages11
JournalAmerican Journal of Neuroradiology
Volume34
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Outcome Assessment (Health Care)
Longitudinal Studies
Pathology
Patient Care
Animal Models
Wounds and Injuries
Brain
Traumatic Brain Injury
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

A decade of DTI in traumatic brain injury : 10 years and 100 articles later. / Hulkower, M. B.; Poliak, D. B.; Rosenbaum, S. B.; Zimmerman, M. E.; Lipton, Michael L.

In: American Journal of Neuroradiology, Vol. 34, No. 11, 11.2013, p. 2064-2074.

Research output: Contribution to journalArticle

Hulkower, M. B. ; Poliak, D. B. ; Rosenbaum, S. B. ; Zimmerman, M. E. ; Lipton, Michael L. / A decade of DTI in traumatic brain injury : 10 years and 100 articles later. In: American Journal of Neuroradiology. 2013 ; Vol. 34, No. 11. pp. 2064-2074.
@article{19fb5c53089f408f84f59d8ea8c7ea51,
title = "A decade of DTI in traumatic brain injury: 10 years and 100 articles later",
abstract = "The past decade has seen an increase in the number of articles reporting the use of DTI to detect brain abnormalities in patients with traumatic brain injury. DTI is well-suited to the interrogation of white matter microstructure, the most important location of pathology in TBI. Additionally, studies in animal models have demonstrated the correlation of DTI findings and TBI pathology. One hundred articles met the inclusion criteria for this quantitative literature review. Despite significant variability in sample characteristics, technical aspects of imaging, and analysis approaches, the consensus is that DTI effectively differentiates patients with TBI and controls, regardless of the severity and timeframe following injury. Furthermore, many have established a relationship between DTI measures and TBI outcomes. However, the heterogeneity of specific outcome measures used limits interpretation of the literature. Similarly, few longitudinal studies have been performed, limiting inferences regarding the long-term predictive utility of DTI. Larger longitudinal studies, using standardized imaging, analysis approaches, and outcome measures will help realize the promise of DTI as a prognostic tool in the care of patients with TBI.",
author = "Hulkower, {M. B.} and Poliak, {D. B.} and Rosenbaum, {S. B.} and Zimmerman, {M. E.} and Lipton, {Michael L.}",
year = "2013",
month = "11",
doi = "10.3174/ajnr.A3395",
language = "English (US)",
volume = "34",
pages = "2064--2074",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "11",

}

TY - JOUR

T1 - A decade of DTI in traumatic brain injury

T2 - 10 years and 100 articles later

AU - Hulkower, M. B.

AU - Poliak, D. B.

AU - Rosenbaum, S. B.

AU - Zimmerman, M. E.

AU - Lipton, Michael L.

PY - 2013/11

Y1 - 2013/11

N2 - The past decade has seen an increase in the number of articles reporting the use of DTI to detect brain abnormalities in patients with traumatic brain injury. DTI is well-suited to the interrogation of white matter microstructure, the most important location of pathology in TBI. Additionally, studies in animal models have demonstrated the correlation of DTI findings and TBI pathology. One hundred articles met the inclusion criteria for this quantitative literature review. Despite significant variability in sample characteristics, technical aspects of imaging, and analysis approaches, the consensus is that DTI effectively differentiates patients with TBI and controls, regardless of the severity and timeframe following injury. Furthermore, many have established a relationship between DTI measures and TBI outcomes. However, the heterogeneity of specific outcome measures used limits interpretation of the literature. Similarly, few longitudinal studies have been performed, limiting inferences regarding the long-term predictive utility of DTI. Larger longitudinal studies, using standardized imaging, analysis approaches, and outcome measures will help realize the promise of DTI as a prognostic tool in the care of patients with TBI.

AB - The past decade has seen an increase in the number of articles reporting the use of DTI to detect brain abnormalities in patients with traumatic brain injury. DTI is well-suited to the interrogation of white matter microstructure, the most important location of pathology in TBI. Additionally, studies in animal models have demonstrated the correlation of DTI findings and TBI pathology. One hundred articles met the inclusion criteria for this quantitative literature review. Despite significant variability in sample characteristics, technical aspects of imaging, and analysis approaches, the consensus is that DTI effectively differentiates patients with TBI and controls, regardless of the severity and timeframe following injury. Furthermore, many have established a relationship between DTI measures and TBI outcomes. However, the heterogeneity of specific outcome measures used limits interpretation of the literature. Similarly, few longitudinal studies have been performed, limiting inferences regarding the long-term predictive utility of DTI. Larger longitudinal studies, using standardized imaging, analysis approaches, and outcome measures will help realize the promise of DTI as a prognostic tool in the care of patients with TBI.

UR - http://www.scopus.com/inward/record.url?scp=84883490331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883490331&partnerID=8YFLogxK

U2 - 10.3174/ajnr.A3395

DO - 10.3174/ajnr.A3395

M3 - Article

C2 - 23306011

AN - SCOPUS:84883490331

VL - 34

SP - 2064

EP - 2074

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 11

ER -