A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections

Marie Claude Rousseau, Eduardo L. Franco, Luisa L. Villa, João P. Sobrinho, Lara Termini, José M. Prado, Thomas E. Rohan

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Human papillomaviruses (HPVs) play an essential role in the etiology of cervical cancer, but besides an established role for sexual transmission, little is known about other risk factors for HPV infection. Risk factors for nononcogenic, oncogenic, and HPV 16 cervical infections were investigated using a cumulative case-control approach nested in an ongoing cohort study of low income women from Sao Paulo, Brazil. HPV DNA was detected and typed by the MY09/11 PCR protocol. Risk factor information was obtained via interviews. In a case-control analysis, we compared women who harbored infections with exclusively nononcogenic types (n = 123), exclusively oncogenic types (n = 94), and any HPV 16 (n = 60) to women remaining HPV- negative (n = 512) throughout 1 year of follow-up. A strong negative association was found between age and oncogenic infections, but not with nononcogenic infections. Oral contraceptive use was strongly and exclusively associated with oncogenic and HPV 16 infections. Markers of sexual activity were associated with all types of infections, although with varying strengths. Our results suggest some important differences in the epidemiological correlates of HPV infection according to oncogenicity that may have implications for the planning of specific preventive strategies aiming at reduction of cervical cancer risk.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume9
Issue number5
StatePublished - May 2000
Externally publishedYes

Fingerprint

Papillomavirus Infections
Case-Control Studies
Human papillomavirus 16
Infection
Uterine Cervical Neoplasms
Oral Contraceptives
Sexual Behavior
Brazil
Cohort Studies
Interviews
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections. / Rousseau, Marie Claude; Franco, Eduardo L.; Villa, Luisa L.; Sobrinho, João P.; Termini, Lara; Prado, José M.; Rohan, Thomas E.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 9, No. 5, 05.2000, p. 469-476.

Research output: Contribution to journalArticle

Rousseau, Marie Claude ; Franco, Eduardo L. ; Villa, Luisa L. ; Sobrinho, João P. ; Termini, Lara ; Prado, José M. ; Rohan, Thomas E. / A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections. In: Cancer Epidemiology Biomarkers and Prevention. 2000 ; Vol. 9, No. 5. pp. 469-476.
@article{4a22e6fb2fd44e44940b4f5bf7fa05c5,
title = "A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections",
abstract = "Human papillomaviruses (HPVs) play an essential role in the etiology of cervical cancer, but besides an established role for sexual transmission, little is known about other risk factors for HPV infection. Risk factors for nononcogenic, oncogenic, and HPV 16 cervical infections were investigated using a cumulative case-control approach nested in an ongoing cohort study of low income women from Sao Paulo, Brazil. HPV DNA was detected and typed by the MY09/11 PCR protocol. Risk factor information was obtained via interviews. In a case-control analysis, we compared women who harbored infections with exclusively nononcogenic types (n = 123), exclusively oncogenic types (n = 94), and any HPV 16 (n = 60) to women remaining HPV- negative (n = 512) throughout 1 year of follow-up. A strong negative association was found between age and oncogenic infections, but not with nononcogenic infections. Oral contraceptive use was strongly and exclusively associated with oncogenic and HPV 16 infections. Markers of sexual activity were associated with all types of infections, although with varying strengths. Our results suggest some important differences in the epidemiological correlates of HPV infection according to oncogenicity that may have implications for the planning of specific preventive strategies aiming at reduction of cervical cancer risk.",
author = "Rousseau, {Marie Claude} and Franco, {Eduardo L.} and Villa, {Luisa L.} and Sobrinho, {Jo{\~a}o P.} and Lara Termini and Prado, {Jos{\'e} M.} and Rohan, {Thomas E.}",
year = "2000",
month = "5",
language = "English (US)",
volume = "9",
pages = "469--476",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - A cumulative case-control study of risk factor profiles for oncogenic and nononcogenic cervical human papillomavirus infections

AU - Rousseau, Marie Claude

AU - Franco, Eduardo L.

AU - Villa, Luisa L.

AU - Sobrinho, João P.

AU - Termini, Lara

AU - Prado, José M.

AU - Rohan, Thomas E.

PY - 2000/5

Y1 - 2000/5

N2 - Human papillomaviruses (HPVs) play an essential role in the etiology of cervical cancer, but besides an established role for sexual transmission, little is known about other risk factors for HPV infection. Risk factors for nononcogenic, oncogenic, and HPV 16 cervical infections were investigated using a cumulative case-control approach nested in an ongoing cohort study of low income women from Sao Paulo, Brazil. HPV DNA was detected and typed by the MY09/11 PCR protocol. Risk factor information was obtained via interviews. In a case-control analysis, we compared women who harbored infections with exclusively nononcogenic types (n = 123), exclusively oncogenic types (n = 94), and any HPV 16 (n = 60) to women remaining HPV- negative (n = 512) throughout 1 year of follow-up. A strong negative association was found between age and oncogenic infections, but not with nononcogenic infections. Oral contraceptive use was strongly and exclusively associated with oncogenic and HPV 16 infections. Markers of sexual activity were associated with all types of infections, although with varying strengths. Our results suggest some important differences in the epidemiological correlates of HPV infection according to oncogenicity that may have implications for the planning of specific preventive strategies aiming at reduction of cervical cancer risk.

AB - Human papillomaviruses (HPVs) play an essential role in the etiology of cervical cancer, but besides an established role for sexual transmission, little is known about other risk factors for HPV infection. Risk factors for nononcogenic, oncogenic, and HPV 16 cervical infections were investigated using a cumulative case-control approach nested in an ongoing cohort study of low income women from Sao Paulo, Brazil. HPV DNA was detected and typed by the MY09/11 PCR protocol. Risk factor information was obtained via interviews. In a case-control analysis, we compared women who harbored infections with exclusively nononcogenic types (n = 123), exclusively oncogenic types (n = 94), and any HPV 16 (n = 60) to women remaining HPV- negative (n = 512) throughout 1 year of follow-up. A strong negative association was found between age and oncogenic infections, but not with nononcogenic infections. Oral contraceptive use was strongly and exclusively associated with oncogenic and HPV 16 infections. Markers of sexual activity were associated with all types of infections, although with varying strengths. Our results suggest some important differences in the epidemiological correlates of HPV infection according to oncogenicity that may have implications for the planning of specific preventive strategies aiming at reduction of cervical cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=0034026765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034026765&partnerID=8YFLogxK

M3 - Article

C2 - 10815691

AN - SCOPUS:0034026765

VL - 9

SP - 469

EP - 476

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 5

ER -