A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease

Carol Magai, Gary J. Kennedy, Carl I. Cohen, David Gomberg

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

A sample of 31 female nursing home patients with late-stage Alzheimer's disease participated in a double-blind clinical trial of the antidepressant medication sertraline. Measures of depression included various objective scales and two measures of facial expressions of emotion coded during a semistructured interview using a facial affect coding system. Repeated- measures ANOVAs at baseline and at the 8-week endpoint indicated that on all measures, both the treatment and placebo groups improved over time, with three of six measures showing a significant time effect. The 'knit-brow' facial measure approached significance for a Treatment x Time effect. Thus, sertraline had no significant benefits over placebo. However, if as we hypothesize, the knit-brow response is more sensitive to signs of depression in advanced dementia, our study justifies the further investigation of the use of sertraline in this population.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalAmerican Journal of Geriatric Psychiatry
Volume8
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Sertraline
Controlled Clinical Trials
Nursing Homes
Alzheimer Disease
Depression
Placebos
Facial Expression
Antidepressive Agents
Dementia
Analysis of Variance
Emotions
Therapeutics
Clinical Trials
Interviews
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease. / Magai, Carol; Kennedy, Gary J.; Cohen, Carl I.; Gomberg, David.

In: American Journal of Geriatric Psychiatry, Vol. 8, No. 1, 2000, p. 66-74.

Research output: Contribution to journalArticle

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