A comparison of the mechanism of action of VP-16-213 and podophyllotoxin

Susan Band Horwitz, John D. Loike

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A comparison of the mechanism of action of VP-16-213 and podophyllotoxin has revealed that although both drugs inhibit nucleoside uptake in HeLa cells, they exhibit other biological properties which are quite distinct. Podophyllotoxin inhibits microtubule assembly in vitro while VP-16-213 has no effect in this system. VP-16-213 induces single-stranded breaks in DNA in HeLa cells, an effect which may explain the cytoxicity of VP-16-213. In contrast to VP-16-213-treated cells, cells treated with podophyllotoxin maintain DNA integrity and show no evidence of single-stranded breaks.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalLloydia
Volume40
Issue number1
StatePublished - 1977

Fingerprint

Podophyllotoxin
Etoposide
mechanism of action
HeLa Cells
cells
nucleosides
DNA
Single-Stranded DNA Breaks
microtubules
Nucleosides
Microtubules
uptake mechanisms
drugs
Cells
podophyllotoxin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Medicine(all)

Cite this

A comparison of the mechanism of action of VP-16-213 and podophyllotoxin. / Band Horwitz, Susan; Loike, John D.

In: Lloydia, Vol. 40, No. 1, 1977, p. 82-89.

Research output: Contribution to journalArticle

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