TY - JOUR
T1 - A comparison of snRNP-associated Sm-autoantigens
T2 - Human N, rat N and human B/B′
AU - Schmauss, Claudia
AU - Mcallister, George
AU - Ohosone, Yasuo
AU - Hardin, John A.
AU - Lerner, Michael R.
PY - 1989/2/25
Y1 - 1989/2/25
N2 - N is a tissue-specific, Sm-epitope bearing, snRNP-associated protein found predominantly in brain. The cDNA sequence encoding human N is compared to those for rat N and human B/B′. The amino acid sequences of human and rat N are 100% conserved. Although the amino acid sequences of N and B/B′ are very similar to each other, B7sol;B′ contains 50 amino acids which are not present in N. On Northern blots the cDNAs encoding N and B/B′ recognize two different RNA species. A comparison of the codon usage, as specified by the open reading frames of N and B/B′ as well as results from Southern blots, show that N and B/B′ are derived from different genes.
AB - N is a tissue-specific, Sm-epitope bearing, snRNP-associated protein found predominantly in brain. The cDNA sequence encoding human N is compared to those for rat N and human B/B′. The amino acid sequences of human and rat N are 100% conserved. Although the amino acid sequences of N and B/B′ are very similar to each other, B7sol;B′ contains 50 amino acids which are not present in N. On Northern blots the cDNAs encoding N and B/B′ recognize two different RNA species. A comparison of the codon usage, as specified by the open reading frames of N and B/B′ as well as results from Southern blots, show that N and B/B′ are derived from different genes.
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U2 - 10.1093/nar/17.4.1733
DO - 10.1093/nar/17.4.1733
M3 - Article
C2 - 2522186
AN - SCOPUS:0024536963
SN - 0305-1048
VL - 17
SP - 1733
EP - 1743
JO - Nucleic acids research
JF - Nucleic acids research
IS - 4
ER -