A comparison of snRNP-associated Sm-autoantigens: Human N, rat N and human B/B′

Claudia Schmauss, George Mcallister, Yasuo Ohosone, John A. Hardin, Michael R. Lerner

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

N is a tissue-specific, Sm-epitope bearing, snRNP-associated protein found predominantly in brain. The cDNA sequence encoding human N is compared to those for rat N and human B/B′. The amino acid sequences of human and rat N are 100% conserved. Although the amino acid sequences of N and B/B′ are very similar to each other, B7sol;B′ contains 50 amino acids which are not present in N. On Northern blots the cDNAs encoding N and B/B′ recognize two different RNA species. A comparison of the codon usage, as specified by the open reading frames of N and B/B′ as well as results from Southern blots, show that N and B/B′ are derived from different genes.

Original languageEnglish (US)
Pages (from-to)1733-1743
Number of pages11
JournalNucleic acids research
Volume17
Issue number4
DOIs
StatePublished - Feb 25 1989

ASJC Scopus subject areas

  • Genetics

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