A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles

T. Yamamoto, A. Hirano

Research output: Contribution to journalArticle

290 Citations (Scopus)

Abstract

Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros-Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15 to 75% more NFTs were shown and more distinctly with the modified Bielschowsky stain than with the Bodian stain. Many of the NFTs in both cases were of eosinophilic and less argentophilic type. Although the NFTs were not counted, the thioflavin S stain seemed to have no apparent advantage over the modified Bielschowsky stain in the demonstration of NFTs.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalNeuropathology and Applied Neurobiology
Volume12
Issue number1
StatePublished - 1986

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Neurofibrillary Tangles
Coloring Agents
Silver
Alzheimer Disease
thioflavin T
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. / Yamamoto, T.; Hirano, A.

In: Neuropathology and Applied Neurobiology, Vol. 12, No. 1, 1986, p. 3-9.

Research output: Contribution to journalArticle

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