A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy

S. Matsumoto, S. Goto, A. Hirano

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called "striosomes". In addition, a number of typical "woolly fibers" were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive "woolly fibers" appcarance was less well recognizable in the GPe from all the PSP patients examined.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalActa Neuropathologica
Volume81
Issue number1
DOIs
StatePublished - Jan 1 1990

Keywords

  • Alzheimer's disease
  • Globus pallidus
  • Met-Enkephalin
  • Progressive supranuclear palsy
  • Striatum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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