A cohort study of nutritional factors and endometrial cancer

Meera G. Jain, Thomas E. Rohan, Geoffrey R. Howe, Anthony B. Miller

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

To evaluate the role of nutritional factors in the etiology of endometrial cancer, we performed a case-cohort analysis using data from women enrolled in the National Breast Screening Study in Canada from 1980 to 1985. For this analysis, a subcohort was constructed by selecting a 10% random sample from the 56,837 women in the dietary cohort. Cases were the 221 women diagnosed with incident adenocarcinoma of the endometrium during follow-up to December 31, 1993 and ascertained by record linkage to the Canadian Cancer Database. Information on usual diet at enrolment and other epidemiological variables was collected by means of self-administered questionnaires. Hazard ratios were obtained from proportional hazards regression models, with estimation of robust standard errors. We found a strong association of endometrial cancer with body mass index > 25 kg/m2 (hazard ratio 2.72, 95% CI: 2.06-3.50). Endometrial cancer risk was not associated significantly with intakes of total energy, carbohydrates, proteins, total fat and major fatty acids, total dietary fiber and various types of fibers, vitamin C, E and A, folic acid, β-carotene, lutein, or cryptoxanthin. Some decrease in risk was noted with relatively high intakes of saturated fat, animal fat or lycopene. The associations observed in the study were independent of total energy intake and most non-dietary risk factors. The study suggests that dietary intakes of energy and most major nutrients are not related to the risk of endometrial cancer among Canadian women.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalEuropean Journal of Epidemiology
Volume16
Issue number10
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Endometrial Neoplasms
Cohort Studies
Energy Intake
Fats
Lutein
Dietary Fiber
Carotenoids
Endometrium
Vitamin A
Vitamin E
Folic Acid
Proportional Hazards Models
Ascorbic Acid
Canada
Adenocarcinoma
Breast
Body Mass Index
Fatty Acids
Carbohydrates
Databases

Keywords

  • Diet
  • Endometrial cancer
  • Macro-nutrients
  • Micro-nutrients
  • Obesity

ASJC Scopus subject areas

  • Epidemiology

Cite this

A cohort study of nutritional factors and endometrial cancer. / Jain, Meera G.; Rohan, Thomas E.; Howe, Geoffrey R.; Miller, Anthony B.

In: European Journal of Epidemiology, Vol. 16, No. 10, 2000, p. 899-905.

Research output: Contribution to journalArticle

Jain, Meera G. ; Rohan, Thomas E. ; Howe, Geoffrey R. ; Miller, Anthony B. / A cohort study of nutritional factors and endometrial cancer. In: European Journal of Epidemiology. 2000 ; Vol. 16, No. 10. pp. 899-905.
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