TY - JOUR
T1 - A cohort study of dietary carotenoids and lung cancer risk in women (Canada)
AU - Rohan, Thomas E.
AU - Jain, Meera
AU - Howe, Geoffrey R.
AU - Miller, Anthony B.
N1 - Funding Information:
This work was supported by a grant from the National Cancer Institute of Canada (Grant no. 7394). We thank Mr Andrew White for preparing the data file for statistical analysis.
PY - 2002
Y1 - 2002
N2 - Objective: To investigate the association between dietary carotenoid intake and lung cancer risk in women. Methods: A case-cohort study was undertaken in the Canadian National Breast Screening Study dietary cohort, which consists of 56,837 women who completed a self-administered dietary questionnaire. The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 196 cohort members were diagnosed with incident lung cancer. For analysis, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 155 cases and 5361 non-cases. Results: When compared to those in the lowest quartile level of intake, the adjusted incidence rate ratios (95% confidence intervals) for those in the highest quartile levels of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein intake were 0.90 (0.51-1.58), 1.40 (0.76-2.59), 0.66 (0.33-1.32), 1.04 (0.61-1.76), and 1.26 (0.70-2.24), respectively; none of the associated tests for trend was statistically significant. Conclusion: These results suggest that there is no association between dietary carotenoid intake and lung cancer risk, at least for the range of intakes observed here.
AB - Objective: To investigate the association between dietary carotenoid intake and lung cancer risk in women. Methods: A case-cohort study was undertaken in the Canadian National Breast Screening Study dietary cohort, which consists of 56,837 women who completed a self-administered dietary questionnaire. The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 196 cohort members were diagnosed with incident lung cancer. For analysis, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 155 cases and 5361 non-cases. Results: When compared to those in the lowest quartile level of intake, the adjusted incidence rate ratios (95% confidence intervals) for those in the highest quartile levels of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein intake were 0.90 (0.51-1.58), 1.40 (0.76-2.59), 0.66 (0.33-1.32), 1.04 (0.61-1.76), and 1.26 (0.70-2.24), respectively; none of the associated tests for trend was statistically significant. Conclusion: These results suggest that there is no association between dietary carotenoid intake and lung cancer risk, at least for the range of intakes observed here.
KW - Carotenoids
KW - Diet
KW - Lung cancer
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U2 - 10.1023/A:1015048619413
DO - 10.1023/A:1015048619413
M3 - Article
C2 - 12020104
AN - SCOPUS:0036224148
SN - 0957-5243
VL - 13
SP - 231
EP - 237
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 3
ER -
