A cohort study of dietary carotenoids and lung cancer risk in women (Canada)

Thomas E. Rohan, Meera Jain, Geoffrey R. Howe, Anthony B. Miller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: To investigate the association between dietary carotenoid intake and lung cancer risk in women. Methods: A case-cohort study was undertaken in the Canadian National Breast Screening Study dietary cohort, which consists of 56,837 women who completed a self-administered dietary questionnaire. The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 196 cohort members were diagnosed with incident lung cancer. For analysis, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 155 cases and 5361 non-cases. Results: When compared to those in the lowest quartile level of intake, the adjusted incidence rate ratios (95% confidence intervals) for those in the highest quartile levels of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein intake were 0.90 (0.51-1.58), 1.40 (0.76-2.59), 0.66 (0.33-1.32), 1.04 (0.61-1.76), and 1.26 (0.70-2.24), respectively; none of the associated tests for trend was statistically significant. Conclusion: These results suggest that there is no association between dietary carotenoid intake and lung cancer risk, at least for the range of intakes observed here.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalCancer Causes and Control
Volume13
Issue number3
DOIs
StatePublished - 2002

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Carotenoids
Canada
Lung Neoplasms
Cohort Studies
Lutein
Breast
Confidence Intervals
Incidence

Keywords

  • Carotenoids
  • Diet
  • Lung cancer

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

A cohort study of dietary carotenoids and lung cancer risk in women (Canada). / Rohan, Thomas E.; Jain, Meera; Howe, Geoffrey R.; Miller, Anthony B.

In: Cancer Causes and Control, Vol. 13, No. 3, 2002, p. 231-237.

Research output: Contribution to journalArticle

Rohan, Thomas E. ; Jain, Meera ; Howe, Geoffrey R. ; Miller, Anthony B. / A cohort study of dietary carotenoids and lung cancer risk in women (Canada). In: Cancer Causes and Control. 2002 ; Vol. 13, No. 3. pp. 231-237.
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