Abstract
BACKGROUND: This cohort study examines the association between cigarette smoking and risk of fibroadenoma. METHODS: The study was conducted among the 56,537 women in the Canadian National Breast Screening Study (NBSS) who completed self-administered lifestyle and dietary questionnaires. (The NBSS is a randomised, controlled trial of screening for breast cancer in women aged 40-59 at recruitment.) Cases were the 222 women who were diagnosed with biopsy-confirmed incident fibroadenoma. For comparative purposes, a subcohort, consisting of a random sample of 5,681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 222 cases and 5,488 non-cases. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were estimated using Poisson regression. RESULTS: Cigarette smoking was associated with reduced risk of fibroadenoma, the IRR (95% CI) for more than 550 cigarette-years of exposure being 0.66 (0.40-1.10). Although the reduction in risk was evident for all smokers combined (ex-smokers and current smokers), it was indicative largely of an inverse association in current smokers, in whom the IRR (95% CI) for > 300 cigarette-years of exposure was 0.49 (0.24-0.98). The results were mostly the same when examined in strata defined by method of detection of fibroadenoma, menopausal status and history of previous breast disease. There was no evidence for a reduction in risk with time since last use of cigarettes. CONCLUSIONS: The results of this study suggest that cigarette smoking is associated with reduced risk of fibroadenoma, especially in current smokers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 297-302 |
| Number of pages | 6 |
| Journal | Journal of Epidemiology and Biostatistics |
| Volume | 4 |
| Issue number | 4 |
| State | Published - 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Epidemiology
Cite this
A cohort study of cigarette smoking and risk of fibroadenoma. / Rohan, Thomas E.; Miller, A. B.
In: Journal of Epidemiology and Biostatistics, Vol. 4, No. 4, 1999, p. 297-302.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A cohort study of cigarette smoking and risk of fibroadenoma.
AU - Rohan, Thomas E.
AU - Miller, A. B.
PY - 1999
Y1 - 1999
N2 - BACKGROUND: This cohort study examines the association between cigarette smoking and risk of fibroadenoma. METHODS: The study was conducted among the 56,537 women in the Canadian National Breast Screening Study (NBSS) who completed self-administered lifestyle and dietary questionnaires. (The NBSS is a randomised, controlled trial of screening for breast cancer in women aged 40-59 at recruitment.) Cases were the 222 women who were diagnosed with biopsy-confirmed incident fibroadenoma. For comparative purposes, a subcohort, consisting of a random sample of 5,681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 222 cases and 5,488 non-cases. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were estimated using Poisson regression. RESULTS: Cigarette smoking was associated with reduced risk of fibroadenoma, the IRR (95% CI) for more than 550 cigarette-years of exposure being 0.66 (0.40-1.10). Although the reduction in risk was evident for all smokers combined (ex-smokers and current smokers), it was indicative largely of an inverse association in current smokers, in whom the IRR (95% CI) for > 300 cigarette-years of exposure was 0.49 (0.24-0.98). The results were mostly the same when examined in strata defined by method of detection of fibroadenoma, menopausal status and history of previous breast disease. There was no evidence for a reduction in risk with time since last use of cigarettes. CONCLUSIONS: The results of this study suggest that cigarette smoking is associated with reduced risk of fibroadenoma, especially in current smokers.
AB - BACKGROUND: This cohort study examines the association between cigarette smoking and risk of fibroadenoma. METHODS: The study was conducted among the 56,537 women in the Canadian National Breast Screening Study (NBSS) who completed self-administered lifestyle and dietary questionnaires. (The NBSS is a randomised, controlled trial of screening for breast cancer in women aged 40-59 at recruitment.) Cases were the 222 women who were diagnosed with biopsy-confirmed incident fibroadenoma. For comparative purposes, a subcohort, consisting of a random sample of 5,681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 222 cases and 5,488 non-cases. Incidence rate ratios (IRR) and 95% confidence intervals (CI) were estimated using Poisson regression. RESULTS: Cigarette smoking was associated with reduced risk of fibroadenoma, the IRR (95% CI) for more than 550 cigarette-years of exposure being 0.66 (0.40-1.10). Although the reduction in risk was evident for all smokers combined (ex-smokers and current smokers), it was indicative largely of an inverse association in current smokers, in whom the IRR (95% CI) for > 300 cigarette-years of exposure was 0.49 (0.24-0.98). The results were mostly the same when examined in strata defined by method of detection of fibroadenoma, menopausal status and history of previous breast disease. There was no evidence for a reduction in risk with time since last use of cigarettes. CONCLUSIONS: The results of this study suggest that cigarette smoking is associated with reduced risk of fibroadenoma, especially in current smokers.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033289779&partnerID=8YFLogxK
M3 - Article
C2 - 10764243
AN - SCOPUS:0033289779
VL - 4
SP - 297
EP - 302
JO - Journal of Epidemiology and Biostatistics
JF - Journal of Epidemiology and Biostatistics
SN - 1359-5229
IS - 4
ER -