The study of the covalent modifications of the N-terminal tails of histones and their effects on chromatin structure and function, known as 'the histone code', is proceeding at a rapid pace. Recent work by several groups suggests that coactivators, such as p300/CBP, are also controlled by an array of various covalent modifications. This suggests the existence of a 'coactivator code' for p300/CBP and other seemingly promiscuous coregulators. Such a code could have wide-reaching implications for conferring specificity to general, ubiquitous transcriptional regulatory factors.
ASJC Scopus subject areas
- Molecular Biology