TY - JOUR
T1 - A coactivator code for transcription
AU - Gamble, Matthew J.
AU - Freedman, Leonard P.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002/4/1
Y1 - 2002/4/1
N2 - The study of the covalent modifications of the N-terminal tails of histones and their effects on chromatin structure and function, known as 'the histone code', is proceeding at a rapid pace. Recent work by several groups suggests that coactivators, such as p300/CBP, are also controlled by an array of various covalent modifications. This suggests the existence of a 'coactivator code' for p300/CBP and other seemingly promiscuous coregulators. Such a code could have wide-reaching implications for conferring specificity to general, ubiquitous transcriptional regulatory factors.
AB - The study of the covalent modifications of the N-terminal tails of histones and their effects on chromatin structure and function, known as 'the histone code', is proceeding at a rapid pace. Recent work by several groups suggests that coactivators, such as p300/CBP, are also controlled by an array of various covalent modifications. This suggests the existence of a 'coactivator code' for p300/CBP and other seemingly promiscuous coregulators. Such a code could have wide-reaching implications for conferring specificity to general, ubiquitous transcriptional regulatory factors.
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U2 - 10.1016/S0968-0004(02)02076-5
DO - 10.1016/S0968-0004(02)02076-5
M3 - Review article
C2 - 11943535
AN - SCOPUS:0036534434
SN - 0968-0004
VL - 27
SP - 165
EP - 167
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 4
ER -