A coactivator code for transcription

Matthew J. Gamble, Leonard P. Freedman

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

The study of the covalent modifications of the N-terminal tails of histones and their effects on chromatin structure and function, known as 'the histone code', is proceeding at a rapid pace. Recent work by several groups suggests that coactivators, such as p300/CBP, are also controlled by an array of various covalent modifications. This suggests the existence of a 'coactivator code' for p300/CBP and other seemingly promiscuous coregulators. Such a code could have wide-reaching implications for conferring specificity to general, ubiquitous transcriptional regulatory factors.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalTrends in Biochemical Sciences
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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