A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic-ovary syndrome

B. Zumoff, R. Freeman, Susan M. Coupey, P. Saenger, Morri E. Markowitz, J. Kream

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

We investigated possible abnormalities of central-nervous-system regulation of luteinizing hormone secretion in the polycystic-ovary syndrome by determining the plasma concentrations of luteinizing hormone over a 24-hour period in five teenage girls with the syndrome; profiles of prolactin and cortisol were also obtained. Four of the five patients had strikingly abnormal plasma luteinizing hormone profiles: whereas normal pubertal girls have a daily surge in secretion of luteinizing hormone that is coterminous with their nocturnal sleep period, our patients had surges that were grossly desynchronized from their sleep period, occurring seven to eight hours later in the daytime than normal. The chronobiologic disturbance involved only luteinizing hormone; the profiles of cortisol and prolactin were normal. This finding points to the central nervous system as the probable locus of the initiating pathophysiology of polycystic-ovary syndrome.

Original languageEnglish (US)
Pages (from-to)1206-1209
Number of pages4
JournalNew England Journal of Medicine
Volume309
Issue number20
StatePublished - 1983

Fingerprint

Polycystic Ovary Syndrome
Luteinizing Hormone
Prolactin
Hydrocortisone
Sleep
Central Nervous System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic-ovary syndrome. / Zumoff, B.; Freeman, R.; Coupey, Susan M.; Saenger, P.; Markowitz, Morri E.; Kream, J.

In: New England Journal of Medicine, Vol. 309, No. 20, 1983, p. 1206-1209.

Research output: Contribution to journalArticle

@article{816e668317b342f0831a619e4866c826,
title = "A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic-ovary syndrome",
abstract = "We investigated possible abnormalities of central-nervous-system regulation of luteinizing hormone secretion in the polycystic-ovary syndrome by determining the plasma concentrations of luteinizing hormone over a 24-hour period in five teenage girls with the syndrome; profiles of prolactin and cortisol were also obtained. Four of the five patients had strikingly abnormal plasma luteinizing hormone profiles: whereas normal pubertal girls have a daily surge in secretion of luteinizing hormone that is coterminous with their nocturnal sleep period, our patients had surges that were grossly desynchronized from their sleep period, occurring seven to eight hours later in the daytime than normal. The chronobiologic disturbance involved only luteinizing hormone; the profiles of cortisol and prolactin were normal. This finding points to the central nervous system as the probable locus of the initiating pathophysiology of polycystic-ovary syndrome.",
author = "B. Zumoff and R. Freeman and Coupey, {Susan M.} and P. Saenger and Markowitz, {Morri E.} and J. Kream",
year = "1983",
language = "English (US)",
volume = "309",
pages = "1206--1209",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "20",

}

TY - JOUR

T1 - A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic-ovary syndrome

AU - Zumoff, B.

AU - Freeman, R.

AU - Coupey, Susan M.

AU - Saenger, P.

AU - Markowitz, Morri E.

AU - Kream, J.

PY - 1983

Y1 - 1983

N2 - We investigated possible abnormalities of central-nervous-system regulation of luteinizing hormone secretion in the polycystic-ovary syndrome by determining the plasma concentrations of luteinizing hormone over a 24-hour period in five teenage girls with the syndrome; profiles of prolactin and cortisol were also obtained. Four of the five patients had strikingly abnormal plasma luteinizing hormone profiles: whereas normal pubertal girls have a daily surge in secretion of luteinizing hormone that is coterminous with their nocturnal sleep period, our patients had surges that were grossly desynchronized from their sleep period, occurring seven to eight hours later in the daytime than normal. The chronobiologic disturbance involved only luteinizing hormone; the profiles of cortisol and prolactin were normal. This finding points to the central nervous system as the probable locus of the initiating pathophysiology of polycystic-ovary syndrome.

AB - We investigated possible abnormalities of central-nervous-system regulation of luteinizing hormone secretion in the polycystic-ovary syndrome by determining the plasma concentrations of luteinizing hormone over a 24-hour period in five teenage girls with the syndrome; profiles of prolactin and cortisol were also obtained. Four of the five patients had strikingly abnormal plasma luteinizing hormone profiles: whereas normal pubertal girls have a daily surge in secretion of luteinizing hormone that is coterminous with their nocturnal sleep period, our patients had surges that were grossly desynchronized from their sleep period, occurring seven to eight hours later in the daytime than normal. The chronobiologic disturbance involved only luteinizing hormone; the profiles of cortisol and prolactin were normal. This finding points to the central nervous system as the probable locus of the initiating pathophysiology of polycystic-ovary syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0021027336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021027336&partnerID=8YFLogxK

M3 - Article

VL - 309

SP - 1206

EP - 1209

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 20

ER -