A case report of mantle cell lymphoma manifesting as a foot lesion

Arash Samarghandi, Shradha Ahuja, Sorab Gupta, Ilmana Fulger, Gordana Katava, Yanan Fang

Research output: Contribution to journalArticle

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Abstract

Introduction: Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma that most commonly affects men above the age of 60 years. The disease is called MCL because the tumor cells originate from the mantle zone of the lymph node. The most commonly affected sites are the lymph nodes, bone marrow, gastrointestinal tract, Waldeyer's ring and rarely the skin, breast and central nervous system. Only 22 cases with skin manifestation of MCL have been reported so far. Case: We report the case of a 73-year-old woman who was diagnosed with MCL and underwent treatment, but later relapsed and presented with an ulcerated mass over her right foot. She underwent 6 cycles of chemotherapy with bendamustine plus rituximab and responded with resolution of the foot lesion. Discussion and conclusions: MCL is an aggressive lymphoma with a median overall survival of 3-5 years for advanced disease, while early-stage disease has a better prognosis. It rarely involves the skin. Since cutaneous lesions can be the first manifestation of MCL, awareness of this less common presentation is crucial to establish an early diagnosis and pursue treatment as early as possible, as it significantly impacts the survival rate.

Original languageEnglish (US)
Pages (from-to)S137-S140
JournalTumori
Volume102
DOIs
StatePublished - Nov 1 2016

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Mantle-Cell Lymphoma
Foot
Skin
Lymph Nodes
Skin Manifestations
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Gastrointestinal Tract
Early Diagnosis
Lymphoma
Breast
Survival Rate
Central Nervous System
Bone Marrow
Drug Therapy
Survival
Therapeutics
Neoplasms

Keywords

  • Foot
  • Mantle cell lymphoma
  • Skin

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Samarghandi, A., Ahuja, S., Gupta, S., Fulger, I., Katava, G., & Fang, Y. (2016). A case report of mantle cell lymphoma manifesting as a foot lesion. Tumori, 102, S137-S140. https://doi.org/10.5301/tj.5000449

A case report of mantle cell lymphoma manifesting as a foot lesion. / Samarghandi, Arash; Ahuja, Shradha; Gupta, Sorab; Fulger, Ilmana; Katava, Gordana; Fang, Yanan.

In: Tumori, Vol. 102, 01.11.2016, p. S137-S140.

Research output: Contribution to journalArticle

Samarghandi, A, Ahuja, S, Gupta, S, Fulger, I, Katava, G & Fang, Y 2016, 'A case report of mantle cell lymphoma manifesting as a foot lesion', Tumori, vol. 102, pp. S137-S140. https://doi.org/10.5301/tj.5000449
Samarghandi A, Ahuja S, Gupta S, Fulger I, Katava G, Fang Y. A case report of mantle cell lymphoma manifesting as a foot lesion. Tumori. 2016 Nov 1;102:S137-S140. https://doi.org/10.5301/tj.5000449
Samarghandi, Arash ; Ahuja, Shradha ; Gupta, Sorab ; Fulger, Ilmana ; Katava, Gordana ; Fang, Yanan. / A case report of mantle cell lymphoma manifesting as a foot lesion. In: Tumori. 2016 ; Vol. 102. pp. S137-S140.
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