Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. Case presentation: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. Conclusions: This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.
Original language | English (US) |
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Article number | 7 |
Journal | Biomarker Research |
Volume | 5 |
Issue number | 1 |
DOIs | |
State | Published - 2017 |
Externally published | Yes |
Keywords
- Case report
- Diffuse large B cell lymphoma
- Molecular analysis
- Rhabdomyosarcoma
ASJC Scopus subject areas
- Molecular Medicine
- Clinical Biochemistry
- Biochemistry, medical