A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition

M. D. Mathias, M. V. Ortiz, H. Magnan, S. R. Ambati, E. K. Slotkin, Alexander Ja-Ho Chou, M. F. Walsh, K. Offit, C. Moskowitz, A. Kentsis, L. H. Wexler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. Rhabdomyosarcoma, the most common soft tissue sarcoma of childhood. makes up less than 1% of solid malignancies in adults with around 400 new cases each year in the United States. They have not previously been reported concurrently. Case presentation: A 37 year old woman presented with painful enlarging leg mass. Biopsy of the mass was consistent with embryonal rhabdomyosarcoma. Staging imaging revealed a PET avid anterior mediastinal lymph node. Excisional biopsy of this mass was consistent with diffuse large B-cell lymphoma. Hybridization capture-based next-generation DNA sequencing did not reveal shared somatic tumor mutations. Germline analysis did not show identifiable aberrations of TP53 or other heritable cancer susceptibility genes. She was treated with a personalized chemotherapy regimen combining features of R-CHOP and Children's Oncology Group ARST 0331. Conclusions: This case illustrates a unique clinical entity successfully treated with a personalized chemotherapeutic regimen.

Original languageEnglish (US)
Article number7
JournalBiomarker Research
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Embryonal Rhabdomyosarcoma
Lymphoma, Large B-Cell, Diffuse
Biopsy
Cells
Oncology
Chemotherapy
Rhabdomyosarcoma
Neoplasm Genes
Aberrations
DNA Sequence Analysis
Sarcoma
Non-Hodgkin's Lymphoma
Tumors
Neoplasms
Leg
Genes
Lymph Nodes
Tissue
Imaging techniques
Drug Therapy

Keywords

  • Case report
  • Diffuse large B cell lymphoma
  • Molecular analysis
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition. / Mathias, M. D.; Ortiz, M. V.; Magnan, H.; Ambati, S. R.; Slotkin, E. K.; Chou, Alexander Ja-Ho; Walsh, M. F.; Offit, K.; Moskowitz, C.; Kentsis, A.; Wexler, L. H.

In: Biomarker Research, Vol. 5, No. 1, 7, 01.01.2017.

Research output: Contribution to journalArticle

Mathias, MD, Ortiz, MV, Magnan, H, Ambati, SR, Slotkin, EK, Chou, AJ-H, Walsh, MF, Offit, K, Moskowitz, C, Kentsis, A & Wexler, LH 2017, 'A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition', Biomarker Research, vol. 5, no. 1, 7. https://doi.org/10.1186/s40364-017-0086-7
Mathias, M. D. ; Ortiz, M. V. ; Magnan, H. ; Ambati, S. R. ; Slotkin, E. K. ; Chou, Alexander Ja-Ho ; Walsh, M. F. ; Offit, K. ; Moskowitz, C. ; Kentsis, A. ; Wexler, L. H. / A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition. In: Biomarker Research. 2017 ; Vol. 5, No. 1.
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