A Case of Vanishing Metastatic Mass: Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine

Eshan Patel, P. Kancharla, B. K. Surapaneni, K. Hennrick, M. Goldfinger, M. Kalavar

Research output: Contribution to journalArticle

Abstract

Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium. This is the first documented case of EHE of the spine with metastatic spread to the heart treated with bevacizumab leading to resolution of the heart metastatic mass. Further studies are warranted to develop a treatment formula for this rare tumor, to consider combination chemotherapy and new adjuvant targeted immunotherapies to prevent progression of disease.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalCase Reports in Oncology
Volume11
Issue number2
DOIs
StatePublished - May 1 2018
Externally publishedYes

Fingerprint

Epithelioid Hemangioendothelioma
Spine
Vascular Neoplasms
Hemangiosarcoma
Hemangioma
Combination Drug Therapy
Heart Atria
Immunotherapy
Disease Progression
Neoplasm Metastasis
Bone and Bones
Lung
Skin
Liver
Therapeutics
Neoplasms

Keywords

  • Epithelioid hemangioendothelioma
  • Right atrium
  • Spine

ASJC Scopus subject areas

  • Oncology

Cite this

A Case of Vanishing Metastatic Mass : Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine. / Patel, Eshan; Kancharla, P.; Surapaneni, B. K.; Hennrick, K.; Goldfinger, M.; Kalavar, M.

In: Case Reports in Oncology, Vol. 11, No. 2, 01.05.2018, p. 534-540.

Research output: Contribution to journalArticle

Patel, Eshan ; Kancharla, P. ; Surapaneni, B. K. ; Hennrick, K. ; Goldfinger, M. ; Kalavar, M. / A Case of Vanishing Metastatic Mass : Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine. In: Case Reports in Oncology. 2018 ; Vol. 11, No. 2. pp. 534-540.
@article{e11b65a4d98c4dc29eb9cc144bf8421c,
title = "A Case of Vanishing Metastatic Mass: Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine",
abstract = "Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium. This is the first documented case of EHE of the spine with metastatic spread to the heart treated with bevacizumab leading to resolution of the heart metastatic mass. Further studies are warranted to develop a treatment formula for this rare tumor, to consider combination chemotherapy and new adjuvant targeted immunotherapies to prevent progression of disease.",
keywords = "Epithelioid hemangioendothelioma, Right atrium, Spine",
author = "Eshan Patel and P. Kancharla and Surapaneni, {B. K.} and K. Hennrick and M. Goldfinger and M. Kalavar",
year = "2018",
month = "5",
day = "1",
doi = "10.1159/000491529",
language = "English (US)",
volume = "11",
pages = "534--540",
journal = "Case Reports in Oncology",
issn = "1662-6575",
number = "2",

}

TY - JOUR

T1 - A Case of Vanishing Metastatic Mass

T2 - Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine

AU - Patel, Eshan

AU - Kancharla, P.

AU - Surapaneni, B. K.

AU - Hennrick, K.

AU - Goldfinger, M.

AU - Kalavar, M.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium. This is the first documented case of EHE of the spine with metastatic spread to the heart treated with bevacizumab leading to resolution of the heart metastatic mass. Further studies are warranted to develop a treatment formula for this rare tumor, to consider combination chemotherapy and new adjuvant targeted immunotherapies to prevent progression of disease.

AB - Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium. This is the first documented case of EHE of the spine with metastatic spread to the heart treated with bevacizumab leading to resolution of the heart metastatic mass. Further studies are warranted to develop a treatment formula for this rare tumor, to consider combination chemotherapy and new adjuvant targeted immunotherapies to prevent progression of disease.

KW - Epithelioid hemangioendothelioma

KW - Right atrium

KW - Spine

UR - http://www.scopus.com/inward/record.url?scp=85052657164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052657164&partnerID=8YFLogxK

U2 - 10.1159/000491529

DO - 10.1159/000491529

M3 - Article

AN - SCOPUS:85052657164

VL - 11

SP - 534

EP - 540

JO - Case Reports in Oncology

JF - Case Reports in Oncology

SN - 1662-6575

IS - 2

ER -