A case of down’s syndrome with diffuse lewy body disease and alzheimerဩs disease

Surender Bodhireddy, Dennis W. Dickson, Linda Mattiace, Karen M. Weidenheim

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Almost all Down’s syndrome (DS) patients over the age of 35 to 40 years have histologic features of Alzheimer’s disease (AD). However, the presence of extrapyramidal features in up to 364 of these patients has no satisfactory pathologic explanation. We report an older patient with DS, dementia, and parkinsonian signs who showed pathologic changes of Parkinson's disease and cortical Lewy bodies in addition to AD. These parkinsonian changes may be related to chromosome 21 abnormalities.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalNeurology
Volume44
Issue number1
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Clinical Neurology

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    Bodhireddy, S., Dickson, D. W., Mattiace, L., & Weidenheim, K. M. (1994). A case of down’s syndrome with diffuse lewy body disease and alzheimerဩs disease. Neurology, 44(1), 159-161.