A case of acute renal failure in a patient recently treated with clozapine and a review of previously reported cases

J. Daniel Kanofsky, Mary E. Woesner, Alexander Z. Harris, James P. Kelleher, Karen Gittens, Elina Jerschow

Research output: Contribution to journalReview article

15 Scopus citations


Clozapine has been reported to cause acute renal failure due to acute interstitial nephritis. We discuss a case of clozapine-induced acute renal failure and compare it to 7 other cases reported in the literature. We review the signs and symptoms of the hypersensitivity response, such as fever and eosinophilia, caused by clozapine and make recommendations for early detection. Early detection and prompt discontinuation of clozapine can prevent renal damage, as can the avoidance of other nephrotoxic drugs like antibiotics.

Original languageEnglish (US)
JournalPrimary Care Companion to the Journal of Clinical Psychiatry
Issue number3
StatePublished - Jul 18 2011


ASJC Scopus subject areas

  • Psychiatry and Mental health

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