A C. elegans CLIC-like Protein Required for Intracellular Tube Formation and Maintenance

Katherine L. Berry, Hannes E. Bülow, David H. Hall, Oliver Hobert

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55-amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.

Original languageEnglish (US)
Pages (from-to)2134-2137
Number of pages4
JournalScience
Volume302
Issue number5653
DOIs
StatePublished - Dec 19 2003

ASJC Scopus subject areas

  • General

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