A brief introduction to tiling microarrays: Principles, concepts, and applications

Christophe Lemetre, Zhengdong D. Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Technological achievements have always contributed to the advancement of biomedical research. It has never been more so than in recent times, when the development and application of innovative cutting-edge technologies have transformed biology into a data-rich quantitative science. This stunning revolution in biology primarily ensued from the emergence of microarrays over two decades ago. The completion of whole-genome sequencing projects and the advance in microarray manufacturing technologies enabled the development of tiling microarrays, which gave unprecedented genomic coverage. Since their first description, several types of application of tiling arrays have emerged, each aiming to tackle a different biological problem. Although numerous algorithms have already been developed to analyze microarray data, new method development is still needed not only for better performance but also for integration of available microarray data sets, which without doubt constitute one of the largest collections of biological data ever generated. In this chapter we first introduce the principles behind the emergence and the development of tiling microarrays, and then discuss with some examples how they are used to investigate different biological problems.

Original languageEnglish (US)
Title of host publicationTiling Arrays
Subtitle of host publicationMethods and Protocols
EditorsTin-Lap Lee, Alfred Chun Shui Luk
Pages3-19
Number of pages17
DOIs
StatePublished - Sep 20 2013

Publication series

NameMethods in Molecular Biology
Volume1067
ISSN (Print)1064-3745

Keywords

  • ChIP-chip
  • Gene expression
  • Probe design
  • Tiling microarrays
  • Transcriptome mapping

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Lemetre, C., & Zhang, Z. D. (2013). A brief introduction to tiling microarrays: Principles, concepts, and applications. In T-L. Lee, & A. C. S. Luk (Eds.), Tiling Arrays: Methods and Protocols (pp. 3-19). (Methods in Molecular Biology; Vol. 1067). https://doi.org/10.1007/978-1-62703-607-8_1