A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells

Myles Akabas, Jane Dodd, Qais Al-Awqati

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

The sense of taste permits animals to discriminate between foods that are safe and those that are toxic. Because most poisonous plant alkaloids are intensely bitter, bitter taste warns animals of potentially hazardous foods. To investigate the mechanism of bitter taste transduction, a preparation of dissociated rat taste cells was developed that can be studied with techniques designed for single-cell measurements. Denatonium, a very bitter substance, caused a rise in the intracellular calcium concentration due to release from internal stores in a small subpopulation of taste cells. Thus, the transduction of bitter taste may occur via a receptor-second messenger mechanism leading to neurotransmitter release and may not involve depolarization-mediated calcium entry.

Original languageEnglish (US)
Pages (from-to)1047-1050
Number of pages4
JournalScience
Volume242
Issue number4881
StatePublished - 1988
Externally publishedYes

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Calcium
Toxic Plants
Food
Poisons
Second Messenger Systems
Alkaloids
Neurotransmitter Agents

ASJC Scopus subject areas

  • General

Cite this

A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells. / Akabas, Myles; Dodd, Jane; Al-Awqati, Qais.

In: Science, Vol. 242, No. 4881, 1988, p. 1047-1050.

Research output: Contribution to journalArticle

Akabas, Myles ; Dodd, Jane ; Al-Awqati, Qais. / A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells. In: Science. 1988 ; Vol. 242, No. 4881. pp. 1047-1050.
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