A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States)

Ilir Agalliu, Ellen A. Eisen, David Kriebel, Margaret M. Quinn, David H. Wegman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Prostate cancer is hormone-related and chemicals that interfere with hormones may contribute to carcinogenesis. In a cohort of autoworkers we characterized exposure to metalworking fluids (MWF) into age windows with homogenous biological risk for prostate cancer, and examined exposure-response relationships using semi-parametric modeling. Methods: Incident cases (n=872) were identified via Michigan cancer registry from 1985 through 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using a hormonal-based model, exposure was accumulated in three windows: (1) late puberty, (2) adulthood, and (3) middle age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar year of diagnosis in a Cox model. Results: Risk of prostate cancer linearly increased with exposure to straight MWF in the first window, with a relative risk of 2.4 per 10 mg/m3-years. Autoworkers exposed to MWF at a young age also had an increased risk associated with MWF exposure incurred later in life. For soluble MWF there was a slightly increased risk in the third window. Conclusions: Exposure characterization based on a hormonal model identified heightened risk with early age of exposure to straight MWF. Results also support a long latency period for exposure related prostate cancer.

Original languageEnglish (US)
Pages (from-to)323-331
Number of pages9
JournalCancer Causes and Control
Volume16
Issue number4
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Hormones
Puberty
Proportional Hazards Models
Registries
Carcinogenesis
Incidence
Neoplasms

Keywords

  • Exposure windows
  • Hormone-related cancer
  • Latency of cancer
  • Penalized splines

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States). / Agalliu, Ilir; Eisen, Ellen A.; Kriebel, David; Quinn, Margaret M.; Wegman, David H.

In: Cancer Causes and Control, Vol. 16, No. 4, 05.2005, p. 323-331.

Research output: Contribution to journalArticle

Agalliu, Ilir ; Eisen, Ellen A. ; Kriebel, David ; Quinn, Margaret M. ; Wegman, David H. / A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States). In: Cancer Causes and Control. 2005 ; Vol. 16, No. 4. pp. 323-331.
@article{1e1d194bde47443dad50ebb300e3659e,
title = "A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States)",
abstract = "Objective: Prostate cancer is hormone-related and chemicals that interfere with hormones may contribute to carcinogenesis. In a cohort of autoworkers we characterized exposure to metalworking fluids (MWF) into age windows with homogenous biological risk for prostate cancer, and examined exposure-response relationships using semi-parametric modeling. Methods: Incident cases (n=872) were identified via Michigan cancer registry from 1985 through 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using a hormonal-based model, exposure was accumulated in three windows: (1) late puberty, (2) adulthood, and (3) middle age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar year of diagnosis in a Cox model. Results: Risk of prostate cancer linearly increased with exposure to straight MWF in the first window, with a relative risk of 2.4 per 10 mg/m3-years. Autoworkers exposed to MWF at a young age also had an increased risk associated with MWF exposure incurred later in life. For soluble MWF there was a slightly increased risk in the third window. Conclusions: Exposure characterization based on a hormonal model identified heightened risk with early age of exposure to straight MWF. Results also support a long latency period for exposure related prostate cancer.",
keywords = "Exposure windows, Hormone-related cancer, Latency of cancer, Penalized splines",
author = "Ilir Agalliu and Eisen, {Ellen A.} and David Kriebel and Quinn, {Margaret M.} and Wegman, {David H.}",
year = "2005",
month = "5",
doi = "10.1007/s10552-004-4323-7",
language = "English (US)",
volume = "16",
pages = "323--331",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - A biological approach to characterizing exposure to metalworking fluids and risk of prostate cancer (United States)

AU - Agalliu, Ilir

AU - Eisen, Ellen A.

AU - Kriebel, David

AU - Quinn, Margaret M.

AU - Wegman, David H.

PY - 2005/5

Y1 - 2005/5

N2 - Objective: Prostate cancer is hormone-related and chemicals that interfere with hormones may contribute to carcinogenesis. In a cohort of autoworkers we characterized exposure to metalworking fluids (MWF) into age windows with homogenous biological risk for prostate cancer, and examined exposure-response relationships using semi-parametric modeling. Methods: Incident cases (n=872) were identified via Michigan cancer registry from 1985 through 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using a hormonal-based model, exposure was accumulated in three windows: (1) late puberty, (2) adulthood, and (3) middle age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar year of diagnosis in a Cox model. Results: Risk of prostate cancer linearly increased with exposure to straight MWF in the first window, with a relative risk of 2.4 per 10 mg/m3-years. Autoworkers exposed to MWF at a young age also had an increased risk associated with MWF exposure incurred later in life. For soluble MWF there was a slightly increased risk in the third window. Conclusions: Exposure characterization based on a hormonal model identified heightened risk with early age of exposure to straight MWF. Results also support a long latency period for exposure related prostate cancer.

AB - Objective: Prostate cancer is hormone-related and chemicals that interfere with hormones may contribute to carcinogenesis. In a cohort of autoworkers we characterized exposure to metalworking fluids (MWF) into age windows with homogenous biological risk for prostate cancer, and examined exposure-response relationships using semi-parametric modeling. Methods: Incident cases (n=872) were identified via Michigan cancer registry from 1985 through 2000. Controls were selected using incidence-density sampling, 5:1 ratio. Using a hormonal-based model, exposure was accumulated in three windows: (1) late puberty, (2) adulthood, and (3) middle age. We used penalized splines to model risk as a smooth function of exposure, and controlled for race and calendar year of diagnosis in a Cox model. Results: Risk of prostate cancer linearly increased with exposure to straight MWF in the first window, with a relative risk of 2.4 per 10 mg/m3-years. Autoworkers exposed to MWF at a young age also had an increased risk associated with MWF exposure incurred later in life. For soluble MWF there was a slightly increased risk in the third window. Conclusions: Exposure characterization based on a hormonal model identified heightened risk with early age of exposure to straight MWF. Results also support a long latency period for exposure related prostate cancer.

KW - Exposure windows

KW - Hormone-related cancer

KW - Latency of cancer

KW - Penalized splines

UR - http://www.scopus.com/inward/record.url?scp=21244501026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21244501026&partnerID=8YFLogxK

U2 - 10.1007/s10552-004-4323-7

DO - 10.1007/s10552-004-4323-7

M3 - Article

VL - 16

SP - 323

EP - 331

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 4

ER -