Find Research outputs

Search results

• Article

  Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

  Roberts, K. G., Li, Y., Payne-Turner, D., Harvey, R. C., Yang, Y. L., Pei, D., McCastlain, K., Ding, L., Lu, C., Song, G., Ma, J., Becksfort, J., Rusch, M., Chen, S. C., Easton, J., Cheng, J., Boggs, K., Santiago-Morales, N., Iacobucci, I., Fulton, R. S., & 54 othersWen, J., Valentine, M., Cheng, C., Paugh, S. W., Devidas, M., Chen, I. M., Reshmi, S., Smith, A., Hedlund, E., Gupta, P., Nagahawatte, P., Wu, G., Chen, X., Yergeau, D., Vadodaria, B., Mulder, H., Winick, N. J., Larsen, E. C., Carroll, W. L., Heerema, N. A., Carroll, A. J., Grayson, G., Tasian, S. K., Moore, A. S., Keller, F., Frei-Jones, M., Whitlock, J. A., Raetz, E. A., White, D. L., Hughes, T. P., Guidry Auvil, J. M., Smith, M. A., Marcucci, G., Bloomfield, C. D., Mrózek, K., Kohlschmidt, J., Stock, W., Kornblau, S. M., Konopleva, M., Paietta, E., Pui, C. H., Jeha, S., Relling, M. V., Evans, W. E., Gerhard, D. S., Gastier-Foster, J. M., Mardis, E., Wilson, R. K., Loh, M. L., Downing, J. R., Hunger, S. P., Willman, C. L., Zhang, J. & Mullighan, C. G., Sep 11 2014, In: New England Journal of Medicine. 371, 11, p. 1005-1015 11 p.

  Research output: Contribution to journal › Article › peer-review
  936 Scopus citations

• Target antigens in systemic autoimmune diseases

  Naparstek, Y., Tadmor, B., Putterman, C. & Bar-Tana, R., Jan 1 1994, In: Israel Journal of Medical Sciences. 30, 3, p. 31-33 3 p.

  Research output: Contribution to journal › Article › peer-review

• Target cell susceptibility to lysis by human natural killer cells is augmented by α(1,3)-galactosyltransferase and reduced by α(1,2)- fucosyltransferase

  Artrip, J. H., Kwiatkowski, P., Michler, R. E., Wang, S. F., Tugulea, S., Ankersmit, J., Chisholm, L., McKenzie, I. F. C., Sandrin, M. S. & Itescu, S., Apr 16 1999, In: Journal of Biological Chemistry. 274, 16, p. 10717-10722 6 p.

  Research output: Contribution to journal › Article › peer-review
  53 Scopus citations

• Targeted AKT inhibition in prostate cancer cells and spheroids reduces aerobic glycolysis and generation of hyperpolarized [1-¹³C] lactate

  Tee, S. S., Suster, I., Truong, S., Jeong, S., Eskandari, R., DiGialleonardo, V., Alvarez, J. A., Aldeborgh, H. N. & Keshari, K. R., Mar 1 2018, In: Molecular Cancer Research. 16, 3, p. 453-460 8 p.

  Research output: Contribution to journal › Article › peer-review
  14 Scopus citations

• Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

  Yong, K. J., Basseres, D. S., Welner, R. S., Zhang, W. C., Yang, H., Yan, B., Alberich-Jorda, M., Zhang, J., De Figueiredo-Pontes, L. L., Battelli, C., Hetherington, C. J., Ye, M., Zhang, H., Maroni, G., O'Brien, K., Magli, M. C., Borczuk, A. C., Varticovski, L., Kocher, O., Zhang, P., & 12 othersMoon, Y. C., Sydorenko, N., Cao, L., Davis, T. W., Thakkar, B. M., Soo, R. A., Iwama, A., Lim, B., Halmos, B., Neuberg, D., Tenen, D. G. & Levantini, E., Aug 3 2016, In: Science translational medicine. 8, 350, p. 350ra104

  Research output: Contribution to journal › Article › peer-review
  40 Scopus citations

• Targeted Chemical Disruption of Clathrin Function in Living Cells

  Moskowitz, H. S., Heuser, J., McGraw, T. E. & Ryan, T. A., Nov 2003, In: Molecular biology of the cell. 14, 11, p. 4437-4447 11 p.

  Research output: Contribution to journal › Article › peer-review
  53 Scopus citations

• Targeted cleavage of hepatitis E virus 3′ end RNA mediated by hammerhead ribozymes inhibits viral RNA replication

  Sriram, B., Thakral, D. & Panda, S. K., Aug 1 2003, In: Virology. 312, 2, p. 350-358 9 p.

  Research output: Contribution to journal › Article › peer-review
  15 Scopus citations

• Targeted cleavage of HIV-1 coreceptor-CXCR-4 by RNA-cleaving DNA-enzyme: Inhibition of coreceptor function

  Basu, S., Sriram, B., Goila, R. & Banerjea, A. C., May 2000, In: Antiviral Research. 46, 2, p. 125-134 10 p.

  Research output: Contribution to journal › Article › peer-review
  30 Scopus citations

• Targeted Cleavage of Signaling Proteins by Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells

  Puga, I., Rao, A. & Macian, F., Aug 15 2008, In: Immunity. 29, 2, p. 193-204 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  52 Scopus citations

• Targeted cytotoxic cells as a novel form of cancer immunotherapy

  Segal, D. M., Garrido, M. A., Perez, P., Titus, J. A., Winkler, D. A., Ring, D. B., Kaubisch, A. & Wunderlich, J. R., Nov 1988, In: Molecular Immunology. 25, 11, p. 1099-1103 5 p.

  Research output: Contribution to journal › Article › peer-review
  21 Scopus citations

• Targeted deletion of 5′HS1 and 5′HS4 of the β-globin locus control region reveals additive activity of the DNaseI hypersensitive sites

  Bender, M. A., Roach, J. N., Halow, J., Close, J., Alami, R., Bouhassira, E. E., Groudine, M. & Fiering, S. N., Oct 1 2001, In: Blood. 98, 7, p. 2022-2027 6 p.

  Research output: Contribution to journal › Article › peer-review
  65 Scopus citations

• Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

  Jones, B. W., Deem, J., Younts, T. J., Weisenhaus, M., Sanford, C. A., Slack, M. C., Chin, J., Nachmanson, D., McKennon, A., Castillo, P. E. & McKnight, G. S., Dec 2 2016, In: eLife. 5, DECEMBER2016, e20695.

  Research output: Contribution to journal › Article › peer-review
  23 Scopus citations

• Targeted deletion of the integrin β4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-κB, causing defects in epidermal growth and migration

  Nikolopoulos, S. N., Blaikie, P., Yoshioka, T., Guo, W., Puri, C., Tacchetti, C. & Giancotti, F. G., Jul 2005, In: Molecular and cellular biology. 25, 14, p. 6090-6102 13 p.

  Research output: Contribution to journal › Article › peer-review
  112 Scopus citations

• Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy

  Huang, Z., Zhang, Z., Jiang, Y., Zhang, D., Chen, J., Dong, L. & Zhang, J., Mar 10 2012, In: Journal of Controlled Release. 158, 2, p. 286-292 7 p.

  Research output: Contribution to journal › Article › peer-review
  120 Scopus citations

• Targeted detection and quantitation of histone modifications from 1,000 cells

  Abshiru, N. A., Sikora, J. W., Camarillo, J. M., Morris, J. A., Compton, P. D., Lee, T., Neelamraju, Y., Haddox, S., Sheridan, C., Carroll, M., Cripe, L. D., Tallman, M. S., Paietta, E. M., Melnick, A. M., Thomas, P. M., Garrett-Bakelman, F. E. & Kelleher, N. L., Oct 2020, In: PloS one. 15, 10 October, e0240829.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Scopus citations

• Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

  Enjyoji, K., Sévigny, J., Lin, Y., Frenette, P. S., Christie, P. D., Am Esch, J. S., Imai, M., Edelberg, J. M., Rayburn, H., Lech, M., Beeler, D. L., Csizmadia, E., Wagner, D. D., Robson, S. C. & Rosenberg, R. D., Sep 1999, In: Nature Medicine. 5, 9, p. 1010-1017 8 p.

  Research output: Contribution to journal › Article › peer-review
  480 Scopus citations

• Targeted disruption of the ABP-120 gene leads to cells with altered motility

  Cox, D., Condeelis, J., Wessels, D., Soll, D., Kern, H. & Knecht, D. A., 1992, In: Journal of Cell Biology. 116, 4, p. 943-955 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  94 Scopus citations

• Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice

  Lee, M. P., Ravenel, J. D., Hu, R. J., Lustig, L. R., Tomaselli, G., Berger, R. D., Brandenburg, S. A., Litzi, T. J., Bunton, T. E., Limb, C., Francis, H., Gorelikow, M., Gu, H., Washington, K., Argani, P., Goldenring, J. R., Coffey, R. J. & Feinberg, A. P., 2000, In: Journal of Clinical Investigation. 106, 12, p. 1447-1455 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  252 Scopus citations

• Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects

  Dai, X. M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V. & Stanley, E. R., Jan 1 2002, In: Blood. 99, 1, p. 111-120 10 p.

  Research output: Contribution to journal › Article › peer-review
  830 Scopus citations

• Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis

  Wang, D. Q. H., Schmitz, F., Kopin, A. S. & Carey, M. C., Aug 2004, In: Journal of Clinical Investigation. 114, 4, p. 521-528 8 p.

  Research output: Contribution to journal › Article › peer-review
  82 Scopus citations

• Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis

  Wang, D. Q. H., Schmitz, F., Kopin, A. S. & Carey, M. C., Aug 1 2004, In: Journal of Clinical Investigation. 114, 4, p. 521-528 8 p.

  Research output: Contribution to journal › Article › peer-review

• Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation

  Wang, H. H., Afdhal, N. H., Gendler, S. J. & Wang, D. Q. H., Mar 2004, In: Journal of Lipid Research. 45, 3, p. 438-447 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  38 Scopus citations

• Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

  Galbiati, F., Volonté, D., Engelman, J. A., Watanabe, G., Burk, R., Pestell, R. G. & Lisanti, M. P., Nov 16 1998, In: EMBO Journal. 17, 22, p. 6633-6648 16 p.

  Research output: Contribution to journal › Article › peer-review
  431 Scopus citations

• Targeted expression of an oncogenic adaptor protein v-Crk potentiates axonal growth in dorsal root ganglia and motor neurons in vivo

  Weinstein, D. E., Dobrenis, K. & Birge, R. B., Aug 5 1999, In: Developmental Brain Research. 116, 1, p. 29-39 11 p.

  Research output: Contribution to journal › Article › peer-review
  11 Scopus citations

• Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis

  Gruber, R. C., Ray, A. K., Johndrow, C. T., Guzik, H., Burek, D., De Frutos, P. G. & Shafit-Zagardo, B., Dec 3 2014, In: Journal of Neuroscience. 34, 49, p. 16320-16335 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  34 Scopus citations

• Targeted gene deletion in Candida parapsilosis demonstrates the role of secreted lipase in virulence

  Gácser, A., Trofa, D., Schäfer, W. & Nosanchuk, J. D., Oct 1 2007, In: Journal of Clinical Investigation. 117, 10, p. 3049-3058 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  109 Scopus citations

• Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis

  Lee, J., Saha, P. K., Yang, Q. H., Lee, S., Jung, Y. P., Suh, Y., Lee, S. K., Chan, L., Roeder, R. G. & Lee, J. W., Dec 9 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 49, p. 19229-19234 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  143 Scopus citations

• Targeted inactivation of p27^kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet

  Yang, W. C., Bancroft, L., Nicholas, C., Lozonschi, I. & Augenlicht, L. H., Aug 15 2003, In: Cancer research. 63, 16, p. 4990-4996 7 p.

  Research output: Contribution to journal › Article › peer-review
  50 Scopus citations

• Targeted inactivation of the p21^WAF1/cip1gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosa

  Wan Cai, Y. C., Mathew, J., Velcich, A., Edelmann, W., Kucherlapati, R., Lipkin, M., Yang, K. & Augenlicht, L. H., Jan 15 2001, In: Cancer research. 61, 2, p. 565-569 5 p.

  Research output: Contribution to journal › Article › peer-review
  146 Scopus citations

• Targeted inhibition of farnesyltransferase in locally advanced breast cancer: A phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide

  Sparano, J. A., Moulder, S., Kazi, A., Vahdat, L., Li, T., Pellegrino, C., Munster, P., Malafa, M., Lee, D., Hoschander, S., Hopkins, U., Hershman, D., Wright, J. J. & Sebti, S. M., Jul 1 2006, In: Journal of Clinical Oncology. 24, 19, p. 3013-3018 6 p.

  Research output: Contribution to journal › Article › peer-review
  49 Scopus citations

• Targeted inhibition of the E3 ligase SCFSkp2/Cks1 has antitumor activity in RB1-deficient human and mouse small-cell lung cancer

  Zhao, H., Iqbal, N. J., Sukrithan, V., Nicholas, C., Xue, Y., Yu, C., Locker, J., Zou, J., Schwartz, E. L. & Zhu, L., Jun 2020, In: Cancer research. 80, 11, p. 2355-2367 13 p.

  Research output: Contribution to journal › Article › peer-review
  8 Scopus citations

• Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins

  Dadachova, E., Patel, M. C., Toussi, S., Apostolidis, C., Morgenstern, A., Brechbiel, M. W., Gorny, M. K., Zolla-Pazner, S., Casadevall, A. & Goldstein, H., Nov 2006, In: PLoS Medicine. 3, 11, p. 2094-2103 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  73 Scopus citations

• Targeted loss of ghr signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration

  Vijayakumar, A., Wu, Y. J., Sun, H., Li, X., Jeddy, Z., Liu, C., Schwartz, G. J., Yakar, S. & LeRoith, D., Jan 2012, In: Diabetes. 61, 1, p. 94-103 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  60 Scopus citations

• Targeted metabolic labeling of yeast N-glycans with unnatural sugars

  Breidenbach, M. A., Gallagher, J. E. G., King, D. S., Smart, B. P., Wu, P. & Bertozzi, C. R., Mar 2 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 3988-3993 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  64 Scopus citations

• Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases

  Tsoukalas, D., Fragoulakis, V., Sarandi, E., Docea, A. O., Papakonstaninou, E., Tsilimidos, G., Anamaterou, C., Fragkiadaki, P., Aschner, M., Tsatsakis, A., Drakoulis, N. & Calina, D., Nov 1 2019, In: Frontiers in Molecular Biosciences. 6, 120.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  48 Scopus citations

• Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology

  Patton, A. L., Seely, K. A., Chimalakonda, K. C., Tran, J. P., Trass, M., Miranda, A., Fantegrossi, W. E., Kennedy, P. D., Dobrowolski, P., Radominska-Pandya, A., McCain, K. R., James, L. P., Endres, G. W. & Moran, J. H., Oct 1 2013, In: Analytical Chemistry. 85, 19, p. 9390-9399 10 p.

  Research output: Contribution to journal › Article › peer-review
  30 Scopus citations

• Targeted molecular therapy of anaplastic thyroid carcinoma with AEE788

  Kim, S., Schiff, B. A., Yigitbasi, O. G., Doan, D., Jasser, S. A., Bekele, B. N., Mandal, M. & Myers, J. N., Apr 2005, In: Molecular cancer therapeutics. 4, 4, p. 632-640 9 p.

  Research output: Contribution to journal › Article › peer-review
  46 Scopus citations

• Targeted mutagenesis and functional analysis of adipokinetic hormone-encoding gene in Drosophila

  Sajwan, S., Sidorov, R., Stašková, T., Žaloudíková, A., Takasu, Y., Kodrík, D. & Zurovec, M., Jun 1 2015, In: Insect Biochemistry and Molecular Biology. 61, p. 79-86 8 p.

  Research output: Contribution to journal › Article › peer-review
  27 Scopus citations

• Targeted Mutation of the MLN64 START Domain Causes only Modest Alterations in Cellular Sterol Metabolism

  Kishida, T., Kostetskii, I., Zhang, Z., Martinez, F., Liu, P., Walkley, S. U., Dwyer, N. K., Blanchette-Mackie, E. J., Radice, G. L. & Strauss, J. F., Apr 30 2004, In: Journal of Biological Chemistry. 279, 18, p. 19276-19285 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  76 Scopus citations

• Targeted Next-Generation Sequencing in Molecular Subtyping of Lower-Grade Diffuse Gliomas: Application of the World Health Organization's 2016 Revised Criteria for Central Nervous System Tumors

  Carter, J. H., McNulty, S. N., Cimino, P. J., Cottrell, C. E., Heusel, J. W., Vigh-Conrad, K. A. & Duncavage, E. J., Mar 1 2017, In: Journal of Molecular Diagnostics. 19, 2, p. 328-337 10 p.

  Research output: Contribution to journal › Article › peer-review
  22 Scopus citations

• Targeted overexpression of endothelial nitric oxide synthase in endothelial cells improves cerebrovascular reactivity in Ins2 Akita-type-1 diabetic mice

  Chandra, S. B., Mohan, S., Ford, B. M., Huang, L., Janardhanan, P., Deo, K. S., Cong, L., Muir, E. R. & Duong, T. Q., Jun 1 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 6, p. 1135-1142 8 p.

  Research output: Contribution to journal › Article › peer-review
  12 Scopus citations

• Targeted proteomic scan identifies alteration of serum proteins among workers occupationally exposed to low levels of trichloroethylene

  Hosgood, H. D., Rahman, M. L., Blansky, D., Hu, W., Davitt, M., Wen, C., Huang, Y., Tang, X., Li, L., Smith, M. T., Zhang, L., Vermeulen, R., Rothman, N., Bassig, B. A. & Lan, Q., Dec 2022, In: Environmental and Molecular Mutagenesis. 63, 8-9, p. 423-428 6 p.

  Research output: Contribution to journal › Article › peer-review

• Targeted radionuclide therapies for pancreatic cancer

  Shah, M., Da Silva, R., Gravekamp, C., Libutti, S. K., Abraham, T. & Dadachova, E., Aug 18 2015, In: Cancer gene therapy. 22, 8, p. 375-379 5 p.

  Research output: Contribution to journal › Article › peer-review
  17 Scopus citations

• Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes

  Liu, X., Guo, L., Morris, D., Kane, A. B. & Hurt, R. H., Mar 2008, In: Carbon. 46, 3, p. 489-500 12 p.

  Research output: Contribution to journal › Article › peer-review
  123 Scopus citations

• Targeted sequencing to discover germline variants in the BRCA1 and BRCA2 genes in a Russian population and their association with breast cancer risk

  Solodskikh, S. A., Panevina, A. V., Gryaznova, M. V., Gureev, A. P., Serzhantova, O. V., Mikhailov, A. A., Maslov, A. Y. & Popov, V. N., Jan 2019, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 813, p. 51-57 7 p.

  Research output: Contribution to journal › Article › peer-review
  6 Scopus citations

• Targeted short read sequencing and assembly of re-arrangements and candidate gene loci provide megabase diplotypes

  Shin, G. W., Greer, S. U., Xia, L. C., Lee, H. J., Zhou, J., Boles, T. C. & Ji, H. P., Nov 4 2019, In: Nucleic acids research. 47, 19, p. e115

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Scopus citations

• Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants

  Uko, S., Soghier, L. M., Vega, M., Marsh, J., Reinersman, G. T., Herring, L., Dave, V. A., Nafday, S. & Brion, L. P., 2006, In: Pediatrics. 117, 4, p. 1243-1252 10 p.

  Research output: Contribution to journal › Article › peer-review
  99 Scopus citations

• Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale

  Rachlis, B., Karwa, R., Chema, C., Pastakia, S., Olsson, S., Wools-Kaloustian, K., Jakait, B., Maina, M., Yotebieng, M., Kumarasamy, N., Freeman, A., de Rekeneire, N., Duda, S. N., Davies, M. A. & Braitstein, P., Oct 1 2016, In: Drug Safety. 39, 10, p. 959-976 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Scopus citations

• Targeted therapy of osteosarcoma with radiolabeled monoclonal antibody to an insulin-like growth factor-2 receptor (IGF2R)

  Geller, D. S., Morris, J., Revskaya, E., Kahn, M., Zhang, W., Piperdi, S., Park, A., Koirala, P., Guzik, H., Hall, C., Hoang, B., Yang, R., Roth, M., Gill, J., Gorlick, R. & Dadachova, E., Dec 1 2016, In: Nuclear Medicine and Biology. 43, 12, p. 812-817 6 p.

  Research output: Contribution to journal › Article › peer-review
  23 Scopus citations

• Targeting AID to the Ig genes.

  Li, Z., Luo, Z., Ronai, D., Kuang, F. L., Peled, J. U., Iglesias-Ussel, M. D. & Scharff, M. D., 2007, In: Advances in Experimental Medicine and Biology. 596, p. 93-109 17 p.

  Research output: Contribution to journal › Article › peer-review