Find Research Outputs


CT/MR LI-RADS 2018: clinical implications and management recommendations

Kamath, A., Roudenko, A., Hecht, E., Sirlin, C., Chernyak, V., Fowler, K. & Mitchell, D. G., Jan 1 2019, (Accepted/In press) In : Abdominal Radiology.

Research output: Contribution to journalArticle

Information Systems
Hepatocellular Carcinoma
2 Citations (Scopus)

Cumulative Human Immunodeficiency Viremia, Antiretroviral Therapy, and Incident Myocardial Infarction

Delaney, J. A., Nance, R. M., Whitney, B. M., Crane, H. M., Williams-Nguyen, J., Feinstein, M. J., Kaplan, R. C., Hanna, D. B., Budoff, M. J., Drozd, D. R., Burkholder, G., Mugavero, M. J., Mathews, W. C., Moore, R. D., Eron, J. J., Hunt, P. W., Geng, E., Saag, M. S., Kitahata, M. M. & Heckbert, S. R., Jan 1 2019, In : Epidemiology (Cambridge, Mass.). 30, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle

Myocardial Infarction
Viral Load
Confidence Intervals

Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ

Yang, B., Yin, C., Zhou, Y., Wang, Q., Jiang, Y., Bai, Y., Qian, H., Xing, G., Wang, S., Li, F., Feng, Y., Zhang, Y., Cai, J., Aschner, M. & Lu, R., Sep 1 2019, In : Toxicology. 425, 152248.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Protein Kinase C
6 Citations (Scopus)

Current Landscape of Immunotherapy in Breast Cancer: A Review

Adams, S., Gatti-Mays, M. E., Kalinsky, K., Korde, L. A., Sharon, E., Amiri-Kordestani, L., Bear, H., McArthur, H. L., Frank, E., Perlmutter, J., Page, D. B., Vincent, B., Hayes, J. F., Gulley, J. L., Litton, J. K., Hortobagyi, G. N., Chia, S., Krop, I., White, J., Sparano, J. A. & 2 others, Disis, M. L. & Mittendorf, E. A., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalReview article

Breast Neoplasms
Active Immunotherapy
Tumor Microenvironment
Secondary Prevention

Current Practices and Perspectives on Peer Observation and Feedback: A National Survey

McDaniel, C. E., Singh, A. T., Beck, J. B., Birnie, K., Fromme, H. B., Ginwalla, C. F., Griego, E., King, M., Maniscalco, J., Nazif, J. M., Patra, K. P., Seelbach, E., Walker, J. M. & Bhansali, P., Jan 1 2019, In : Academic Pediatrics.

Research output: Contribution to journalArticle

Surveys and Questionnaires

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis

Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. G. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. K. & Wickrema, A., Jun 1 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access

Cytological Evaluation of Pleomorphic Carcinoma of the Lung

Kuan, K., Khader, S. N. & El Hussein, S., Jan 1 2019, In : Diagnostic Cytopathology.

Research output: Contribution to journalArticle


Cytopathology approach to rare salivary gland lesions with oncocytic features

El Hussein, S. & Khader, S. N., Jan 1 2019, (Accepted/In press) In : Diagnostic Cytopathology.

Research output: Contribution to journalReview article

Salivary Glands
Fine Needle Biopsy
Differential Diagnosis
Needle Biopsy
Fine Needle Biopsy

Daily Intake of Sodium and Potassium Among Diverse US Hispanics/Latinos, the Hispanic Community Health Study/Study of Latinos

Elfassy, T., Sotres-Alvarez, D., Van Horn, L., Angell, S., Schneiderman, N., Rundek, T., Raij, L., Smoller, S. W., Mossavar-Rahmani, Y., Daviglus, M. L., Hanna, D. B. & Zeki Al Hazzouri, A., Aug 14 2019, In : American journal of hypertension. 32, 9, p. 868-879 12 p.

Research output: Contribution to journalArticle

Open Access
Hispanic Americans
Confidence Intervals

Dapsone-Induced Methemoglobinemia in Two Renal Transplant Recipients

Torabi, J., Campbell, A., Nair, G., Patel, G. L., Miura, Y. & Graham, J. A., Jan 1 2019, In : Progress in Transplantation.

Research output: Contribution to journalArticle

Hemic and Lymphatic Diseases
Bacterial Infections and Mycoses
Signs and Symptoms
5 Citations (Scopus)

Deceased-donor acute kidney injury is not associated with kidney allograft failure

Hall, I. E., Akalin, E., Bromberg, J. S., Doshi, M. D., Greene, T., Harhay, M. N., Jia, Y., Mansour, S. G., Mohan, S., Muthukumar, T., Reese, P. P., Schröppel, B., Singh, P., Thiessen-Philbrook, H. R., Weng, F. L. & Parikh, C. R., Jan 1 2019, In : Kidney International. 95, 1, p. 199-209 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Insufficiency
Tissue Donors
Graft Survival

Decellularized bovine placentome for portacavally-interposed heterotopic liver transplantation in rats

Kakabadze, Z., Karalashvili, L., Chakhunashvili, D., Havlioglu, N., Janelidze, M., Kakabadze, A., Sharma, Y. & Gupta, S., Apr 1 2019, In : Materials Science and Engineering C. 97, p. 293-301 9 p.

Research output: Contribution to journalArticle


Decoding Hidden Cognitive States From Behavior and Physiology Using a Bayesian Approach

Yousefi, A., Basu, I., Paulk, A. C., Peled, N., Eskandar, E. N., Dougherty, D. D., Cash, S. S., Widge, A. S. & Eden, U. T., Sep 1 2019, In : Neural computation. 31, 9, p. 1751-1788 38 p.

Research output: Contribution to journalArticle

Bayes Theorem
Patient Selection
Reaction Time
Linear Models

Decoding task engagement from distributed network electrophysiology in humans

Provenza, N. R., Paulk, A. C., Peled, N., Restrepo, M. I., Cash, S. S., Dougherty, D. D., Eskandar, E. N., Borton, D. A. & Widge, A. S., Aug 16 2019, In : Journal of neural engineering. 16, 5, 1 p.

Research output: Contribution to journalArticle

Open Access
Decision making
Decision Making
1 Citation (Scopus)

Decreased Macrophage Autophagy Promotes Liver Injury and Inflammation from Alcohol

Ilyas, G., Cingolani, F., Zhao, E., Tanaka, K. E. & Czaja, M. J., Jan 1 2019, In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

Widge, A. S., Zorowitz, S., Basu, I., Paulk, A. C., Cash, S. S., Eskandar, E. N., Deckersbach, T., Miller, E. K. & Dougherty, D. D., Dec 1 2019, In : Nature Communications. 10, 1, 1536.

Research output: Contribution to journalArticle

Open Access
Internal Capsule
Deep Brain Stimulation
Prefrontal Cortex

Depression Treatment Expenditures for Adults in the USA: a Systematic Review

Breslow, A. S., Tran, N. M., Lu, F. Q., Alpert, J. E. & Cook, B. L., Sep 21 2019, In : Current psychiatry reports. 21, 10, 1 p.

Research output: Contribution to journalReview article

Health Expenditures
Patient Acceptance of Health Care
Delivery of Health Care
Insurance Coverage
2 Citations (Scopus)
Independent Living
Proportional Hazards Models

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Hasenoehrl, E. J., Rae Sajorda, D., Berney-Meyer, L., Johnson, S., Tufariello, J. A. M., Fuhrer, T., Cook, G. M., Jacobs, W. R. & Berney, M., Sep 16 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
infectious diseases
Mycobacterium tuberculosis
Aspartic Acid

Descemet membrane endothelial keratoplasty for endothelial decompensation after previous radial keratotomy

Akella, S. S., Chuck, R. S. & Lee, J. K., Sep 1 2019, In : American Journal of Ophthalmology Case Reports. 15, 100503.

Research output: Contribution to journalArticle

Open Access
Radial Keratotomy
Descemet Membrane
Corneal Transplantation
Descemet Stripping Endothelial Keratoplasty
Patient Satisfaction
1 Citation (Scopus)

Detecting biological heterogeneity patterns in ADNI amnestic mild cognitive impairment based on volumetric MRI

for the Alzheimer’s Disease Neuroimaging Initiative, Jan 1 2019, In : Brain Imaging and Behavior.

Research output: Contribution to journalArticle

Alzheimer Disease
Executive Function

Detection and targeting insulin growth factor receptor type 2 (IGF2R) in osteosarcoma PDX in mouse models and in canine osteosarcoma tumors

Karkare, S., Allen, K. J. H., Jiao, R., Malo, M. E., Dawicki, W., Helal, M., Godson, D. L., Dickinson, R., MacDonald-Dickinson, V., Yang, R., Hoang, B. H., Gorlick, R., Geller, D. S. & Dadachova, E., Dec 1 2019, In : Scientific Reports. 9, 1, 11476.

Research output: Contribution to journalArticle

Open Access
IGF Type 2 Receptor
Growth Factor Receptors
Open Access
radiation therapy

Developing and employing a ‘responsive manualization’ in the ‘Acupuncture Approaches to Decrease Disparities in Outcomes of Pain Treatment’ comparative effectiveness study

Nielsen, A., Anderson, B., Citkovitz, C., Botet, P., Correia, S., Duque, V., Greene, S., Mah, D., Moore, D., Pagliarini, A., McKee, M. D. & Kligler, B., Jan 1 2019, In : Acupuncture in Medicine.

Research output: Contribution to journalArticle

Chronic Pain
Ear Acupuncture

Developing a research mentorship program: The American society of pediatric nephrology's experience

Vasylyeva, T. L., Díaz-González de Ferris, M. E., Hains, D. S., Ho, J., Harshman, L. A., Reidy, K. J., Brady, T. M., Okamura, D. M., Samsonov, D. V., Wenderfer, S. E. & Hartung, E. A., Jan 1 2019, In : Frontiers in Pediatrics. 7, APR, 155.

Research output: Contribution to journalArticle

Open Access
Organized Financing

Development and preliminary results of an Electronic Medical Record (EMR)-integrated smartphone telemedicine program to deliver asthma care remotely

Mammen, J. R., Java, J. J., Halterman, J., Berliant, M. N., Crowley, A., Frey, S. M., Reznik, M., Feldman, J. M., Schoonmaker, J. D. & Arcoleo, K., Jan 1 2019, (Accepted/In press) In : Journal of Telemedicine and Telecare.

Research output: Contribution to journalArticle

Electronic Health Records
Self Care
1 Citation (Scopus)

Development of a claims-based algorithm to identify potentially undiagnosed chronic migraine patients

Pavlovic, J. M., Yu, J. S., Silberstein, S. D., Reed, M. L., Kawahara, S. H., Cowan, R. P., Dabbous, F., Campbell, K. L., Shewale, A. R., Pulicharam, R., Kowalski, J. W., Viswanathan, H. N. & Lipton, R. B., Jan 1 2019, In : Cephalalgia.

Research output: Contribution to journalArticle

Migraine Disorders
International Classification of Diseases
Odds Ratio
Confidence Intervals
2 Citations (Scopus)

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Wec, A. Z., Bornholdt, Z. A., He, S., Herbert, A. S., Goodwin, E., Wirchnianski, A. S., Gunn, B. M., Zhang, Z., Zhu, W., Liu, G., Abelson, D. M., Moyer, C. L., Jangra, R., James, R. M., Bakken, R. R., Bohorova, N., Bohorov, O., Kim, D. H., Pauly, M. H., Velasco, J. & 10 others, Bortz, R. H., Whaley, K. J., Goldstein, T., Anthony, S. J., Alter, G., Walker, L. M., Dye, J. M., Zeitlin, L., Qiu, X. & Chandran, K., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 39-48.e5

Research output: Contribution to journalArticle

Human Development
Antiviral Agents
Guinea Pigs

Development of a Monomeric Inhibitory RNA Aptamer Specific for FGFR3 that Acts as an Activator When Dimerized

Kamatkar, N., Levy, M. & Hebert, J. M., Sep 6 2019, In : Molecular Therapy - Nucleic Acids. 17, p. 530-539 10 p.

Research output: Contribution to journalArticle

Open Access
Nucleotide Aptamers
Fibroblast Growth Factor Receptors
SELEX Aptamer Technique
Neuroepithelial Cells
Cell Line

Development of an Artificially Intelligent Mobile Phone Application to Identify Cardiac Devices on Chest Radiography

Weinreich, M., Chudow, J. J., Weinreich, B., Krumerman, T., Nag, T., Rahgozar, K., Shulman, E., Fisher, J. D. & Ferrick, K. J., Sep 1 2019, In : JACC: Clinical Electrophysiology. 5, 9, p. 1094-1095 2 p.

Research output: Contribution to journalLetter

3 Citations (Scopus)

Development of Quality Measures in Cirrhosis by the Practice Metrics Committee of the American Association for the Study of Liver Diseases

Kanwal, F., Tapper, E. B., Ho, C., Asrani, S. K., Ovchinsky, N., Poterucha, J., Flores, A., Ankoma-Sey, V., Luxon, B. & Volk, M., Apr 1 2019, In : Hepatology. 69, 4, p. 1787-1797 11 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Process Assessment (Health Care)
Quality of Health Care
Outcome Assessment (Health Care)
Open Access
Nasal Sprays
Migraine Disorders

Diabetes Mellitus Modifies the Associations of Serum Magnesium Concentration with Arterial Calcification and Stiffness in Incident Hemodialysis Patients

Chen, W., Fitzpatrick, J., Monroy-Trujillo, J. M., Sozio, S. M., Jaar, B. G., Estrella, M. M., Wu, T. T., Melamed, M. L., Parekh, R. S. & Bushinsky, D. A., Jan 1 2019, In : Kidney International Reports.

Research output: Contribution to journalArticle

Open Access
Vascular Stiffness
Renal Dialysis
Diabetes Mellitus

Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: Meta-analysis of individual patient data

Haase, R., Schlattmann, P., Gueret, P., Andreini, D., Pontone, G., Alkadhi, H., Hausleiter, J., Garcia, M. J., Leschka, S., Meijboom, W. B., Zimmermann, E., Gerber, B., Schoepf, U. J., Shabestari, A. A., Nørgaard, B. L., Meijs, M. F. L., Sato, A., Ovrehus, K. A., Diederichsen, A. C. P., Jenkins, S. M. M. & 51 others, Knuuti, J., Hamdan, A., Halvorsen, B. A., Mendoza-Rodriguez, V., Rochitte, C. E., Rixe, J., Wan, Y. L., Langer, C., Bettencourt, N., Martuscelli, E., Ghostine, S., Buechel, R. R., Nikolaou, K., Mickley, H., Yang, L., Zhang, Z., Chen, M. Y., Halon, D. A., Rief, M., Sun, K., Hirt-Moch, B., Niinuma, H., Marcus, R. P., Muraglia, S., Jakamy, R., Chow, B. J., Kaufmann, P. A., Tardif, J. C., Nomura, C., Kofoed, K. F., Laissy, J. P., Arbab-Zadeh, A., Kitagawa, K., Laham, R., Jinzaki, M., Hoe, J., Rybicki, F. J., Scholte, A., Paul, N., Tan, S. Y., Yoshioka, K., Röhle, R., Schuetz, G. M., Schueler, S., Coenen, M. H., Wieske, V., Achenbach, S., Budoff, M. J., Laule, M., Newby, D. E. & Dewey, M., Jan 1 2019, In : BMJ (Online). 365, el1945.

Research output: Contribution to journalArticle

Open Access
Chest Pain
Coronary Artery Disease
Angina Pectoris
Coronary Angiography
1 Citation (Scopus)

Diagnosis of Urinary Tract Infections by Urine Flow Cytometry: Adjusted Cut-Off Values in Different Clinical Presentations

Schuh, S. K., Seidenberg, R., Arampatzis, S., Leichtle, A. B., Hautz, W. E., Exadaktylos, A. K., Schechter, C. B. & Müller, M., Jan 1 2019, In : Disease markers. 2019, 1 p.

Research output: Contribution to journalArticle

Open Access
Flow cytometry
Urinary Tract Infections
Flow Cytometry
3 Citations (Scopus)

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Winters, M., DuHadaway, J. B., Pham, K. N., Lewis-Ballester, A., Badir, S., Wai, J., Sheikh, E., Yeh, S-R., Prendergast, G. C., Muller, A. J. & Malachowski, W. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 455-464 10 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
1 Citation (Scopus)

Dietary B-Vitamin Intake and Risk of Breast, Endometrial, Ovarian and Colorectal Cancer among Canadians

Arthur, R. S., Kirsh, V. A. & Rohan, T. E., Jan 1 2019, In : Nutrition and Cancer.

Research output: Contribution to journalArticle

Vitamin B Complex
Endometrial Neoplasms
Ovarian Neoplasms
Colorectal Neoplasms
Breast Neoplasms
1 Citation (Scopus)

Differential responses to spectrally degraded speech within human auditory cortex: An intracranial electrophysiology study

Nourski, K. V., Steinschneider, M., Rhone, A. E., Kovach, C. K., Kawasaki, H. & Howard, M. A., Jan 1 2019, In : Hearing Research. 371, p. 53-65 13 p.

Research output: Contribution to journalArticle

Auditory Cortex
Cochlear Implants
Temporal Lobe

Diffusion Tensor Imaging of the Evolving Response to Mild Traumatic Brain Injury in Rats

Hoogenboom, W. S., Rubin, T. G., Ye, Q. K., Cui, M-H., Branch, K. C., Liu, J., Branch, C. A. & Lipton, M. L., Jul 1 2019, In : Journal of Experimental Neuroscience. 13

Research output: Contribution to journalArticle

Open Access
Brain Concussion
Diffusion Tensor Imaging
Wounds and Injuries
Animal Models
1 Citation (Scopus)

Digital Pancreaticocholangioscopy for Mapping of Pancreaticobiliary Neoplasia: Can We Alter the Surgical Resection Margin?

Tyberg, A., Raijman, I., Siddiqui, A., Arnelo, U., Adler, D. G., Xu, M. M., Nassani, N., Sejpal, DI. V., Kedia, P., Nah Lee, Y., Gress, F. G., Ho, S., Gaidhane, M. & Kahaleh, M., Jan 1 2019, In : Journal of Clinical Gastroenterology. 53, 1, p. 71-75 5 p.

Research output: Contribution to journalArticle

Endoscopic Retrograde Cholangiopancreatography
Pancreatic Ducts
Bile Ducts
Margins of Excision

Direct oral factor Xa inhibitors in patients with morbid obesity – Author's reply

Kushnir, M., Sep 1 2019, In : The Lancet Haematology. 6, 9, p. e447

Research output: Contribution to journalLetter

Open Access
Morbid Obesity
Factor Xa Inhibitors

Disability in inflammatory bowel disease patients is associated with race, ethnicity and socio-economic factors

Agrawal, M., Cohen-Mekelburg, S., Kayal, M., Axelrad, J., Galati, J., Tricomi, B., Kamal, K., Faye, A. S., Abrudescu, P., Scherl, E., Lawlor, G., Sultan, K., Lukin, D. J., Colombel, J. F. & Ungaro, R. C., Jan 1 2019, (Accepted/In press) In : Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Odds Ratio
Confidence Intervals
Hispanic Americans

Discharge Heart Rate After Hospitalization for Myocardial Infarction and Long-Term Mortality in 2 US Registries

Alapati, V., Tang, F., Charlap, E., Chan, P. S., Heidenreich, P. A., Jones, P. G., Spertus, J. A., Srinivas, V. & Kizer, J., Feb 5 2019, In : Journal of the American Heart Association. 8, 3, p. e010855

Research output: Contribution to journalArticle

Heart Rate
Myocardial Infarction

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Yuan, Y., Zallot, R., Grove, T. L., Payan, D. J., Martin-Verstraete, I., Šepić, S., Balamkundu, S., Neelakandan, R., Gadi, V. K., Liu, C. F., Swairjo, M. A., Dedon, P. C., Almo, S. C., Gerlt, J. A. & de Crécy-Lagard, V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19126-19135 10 p.

Research output: Contribution to journalArticle

Open Access
queuine tRNA-ribosyltransferase
Nucleoside Q
4 Citations (Scopus)

Disease Activity in Mitral Annular Calcification

Massera, D., Trivieri, M. G., Andrews, J. P. M., Sartori, S., Abgral, R., Chapman, A. R., Jenkins, W. S. A., Vesey, A. T., Doris, M. K., Pawade, T. A., Zheng, K. H., Kizer, J., Newby, D. E. & Dweck, M. R., Feb 1 2019, In : Circulation. Cardiovascular imaging. 12, 2, p. e008513

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18

Disparities in care among patients presenting to the emergency department for urinary stone disease

Schoenfeld, D., Mohn, L., Agalliu, I. & Stern, J. M., Jan 1 2019, In : Urolithiasis.

Research output: Contribution to journalArticle

Urinary Calculi
Hospital Emergency Service
Patient Care
Logistic Models

Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signalling

Nguyen, M. B., Valdes, V. J., Cohen, I., Pothula, V., Zhao, D., Zheng, D. & Ezhkova, E., Jan 1 2019, In : Experimental Dermatology.

Research output: Contribution to journalArticle

Merkel Cells

Distinctive mechanisms underlie the loss of SMARCB1 protein expression in renal medullary carcinoma: morphologic and molecular analysis of 20 cases

Jia, L., Carlo, M. I., Khan, H., Nanjangud, G. J., Rana, S., Cimera, R., Zhang, Y., Hakimi, A. A., Verma, A. K., Al-Ahmadie, H. A., Fine, S. W., Gopalan, A., Sirintrapun, S. J., Tickoo, S. K., Reuter, V. E., Gartrell, B. A. & Chen, Y. B., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Medullary Carcinoma
Fluorescence In Situ Hybridization
Sickle Cell Trait

Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart

Huang, S., Chen, B., Su, Y., Alex, L., Humeres, C., Shinde, A. V., Conway, S. J. & Frangogiannis, N. G., Jul 1 2019, In : Journal of Molecular and Cellular Cardiology. 132, p. 84-97 14 p.

Research output: Contribution to journalArticle

Coronary Occlusion
Myocardial Infarction