4-month-old girl with diffuse, varied dermatitis and bullae

Sarah Fuchs, Alissa C. Baker, Lucinda S. Liu, Brea Prindaville, Richard J. Antaya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

• Pediatric autoimmune blistering disorders are exceedingly rare. Of these, childhood bullous pemphigoid (CBP) is the most common IgG-mediated subepidermal bullous disease in the pediatric population. Tense acral blisters, especially on the soles and palms, are characteristic of the infantile presentation. • Patients with CBP present with varied dermatoses, making clinical diagnosis alone difficult. • Definitive diagnosis is made with direct immunofluorescence revealing linear deposition of IgG and/or C3 at the basement membrane zone (BMZ) or indirect immunofluorescence revealing IgG antibodies reacting with the BMZ. • First-line treatment is oral prednisolone dosed at 1 to 2 mg/kg and then tapered slowly to avoid rebound disease. The length of treatment depends on the rate of remission.

Original languageEnglish (US)
JournalPediatrics in Review
Volume35
Issue number8
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Dermatitis
Blister
Bullous Pemphigoid
Immunoglobulin G
Basement Membrane
Pediatrics
Direct Fluorescent Antibody Technique
Indirect Fluorescent Antibody Technique
Prednisolone
Skin Diseases
Extremities
Antibodies
Therapeutics
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

4-month-old girl with diffuse, varied dermatitis and bullae. / Fuchs, Sarah; Baker, Alissa C.; Liu, Lucinda S.; Prindaville, Brea; Antaya, Richard J.

In: Pediatrics in Review, Vol. 35, No. 8, 01.01.2014.

Research output: Contribution to journalArticle

Fuchs, Sarah ; Baker, Alissa C. ; Liu, Lucinda S. ; Prindaville, Brea ; Antaya, Richard J. / 4-month-old girl with diffuse, varied dermatitis and bullae. In: Pediatrics in Review. 2014 ; Vol. 35, No. 8.
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