Abstract
In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1041-1043 |
| Number of pages | 3 |
| Journal | The Journal of Pediatrics |
| Volume | 88 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia. / Daum, Fredric; Rosen, John F.; Roginsky, Martin; Cohen, Michael I.; Finberg, Laurence.
In: The Journal of Pediatrics, Vol. 88, No. 6, 1976, p. 1041-1043.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia
AU - Daum, Fredric
AU - Rosen, John F.
AU - Roginsky, Martin
AU - Cohen, Michael I.
AU - Finberg, Laurence
PY - 1976
Y1 - 1976
N2 - In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.
AB - In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.
UR - http://www.scopus.com/inward/record.url?scp=0017101238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017101238&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(76)81073-6
DO - 10.1016/S0022-3476(76)81073-6
M3 - Article
C2 - 178851
AN - SCOPUS:0017101238
VL - 88
SP - 1041
EP - 1043
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -