25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia

Fredric Daum, John F. Rosen, Martin Roginsky, Michael I. Cohen, Laurence Finberg

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.

Original languageEnglish (US)
Pages (from-to)1041-1043
Number of pages3
JournalThe Journal of Pediatrics
Volume88
Issue number6
DOIs
StatePublished - 1976
Externally publishedYes

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25-Hydroxyvitamin D 2
Calcifediol
Biliary Atresia
Rickets
Cholecalciferol
Vitamin D
Vitamin D Deficiency
Intestinal Absorption
Hydroxylation
Serum
Liver
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia. / Daum, Fredric; Rosen, John F.; Roginsky, Martin; Cohen, Michael I.; Finberg, Laurence.

In: The Journal of Pediatrics, Vol. 88, No. 6, 1976, p. 1041-1043.

Research output: Contribution to journalArticle

Daum, Fredric ; Rosen, John F. ; Roginsky, Martin ; Cohen, Michael I. ; Finberg, Laurence. / 25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia. In: The Journal of Pediatrics. 1976 ; Vol. 88, No. 6. pp. 1041-1043.
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