Abstract
In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1041-1043 |
| Number of pages | 3 |
| Journal | The Journal of Pediatrics |
| Volume | 88 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1976 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Cite this
Daum, F., Rosen, J. F., Roginsky, M., Cohen, M. I., & Finberg, L. (1976). 25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia. The Journal of Pediatrics, 88(6), 1041-1043. https://doi.org/10.1016/S0022-3476(76)81073-6