25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia

Fredric Daum; John F. Rosen; Martin Roginsky; Michael I. Cohen; Laurence Finberg

doi:10.1016/S0022-3476(76)81073-6

25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia

Fredric Daum, John F. Rosen, Martin Roginsky, Michael I. Cohen, Laurence Finberg

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.

Original language	English (US)
Pages (from-to)	1041-1043
Number of pages	3
Journal	The Journal of Pediatrics
Volume	88
Issue number	6
DOIs	https://doi.org/10.1016/S0022-3476(76)81073-6
State	Published - Jun 1976
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(76)81073-6

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@article{90fdb317479a4ed08c59d9636d593b6a,

title = "25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia",

abstract = "In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.",

author = "Fredric Daum and Rosen, {John F.} and Martin Roginsky and Cohen, {Michael I.} and Laurence Finberg",

note = "Funding Information: From the Department of Pediatrics, Montefiore Hospital and Medical Center, Albert Einstein College of Medicine, and Nassau County Medical Center. Supported by National Institutes of HealCh research grant No. ES 01060-01 awarded by the National Institute of Environmental Health Services, Public Health Service~Department of Health, Education and Welfare. Presented in part at the meeting of the American Pediatric Society, Denver, Colorado, April, 1975. *Reprint address: Department of Pediatrics, Montefiore Hospital and Medical Center, 111 East 210 St., Bronx, N. Y. 10467.",

year = "1976",

month = jun,

doi = "10.1016/S0022-3476(76)81073-6",

language = "English (US)",

volume = "88",

pages = "1041--1043",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Mosby Inc.",

number = "6",

}

TY - JOUR

T1 - 25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia

AU - Daum, Fredric

AU - Rosen, John F.

AU - Roginsky, Martin

AU - Cohen, Michael I.

AU - Finberg, Laurence

N1 - Funding Information: From the Department of Pediatrics, Montefiore Hospital and Medical Center, Albert Einstein College of Medicine, and Nassau County Medical Center. Supported by National Institutes of HealCh research grant No. ES 01060-01 awarded by the National Institute of Environmental Health Services, Public Health Service~Department of Health, Education and Welfare. Presented in part at the meeting of the American Pediatric Society, Denver, Colorado, April, 1975. *Reprint address: Department of Pediatrics, Montefiore Hospital and Medical Center, 111 East 210 St., Bronx, N. Y. 10467.

PY - 1976/6

Y1 - 1976/6

N2 - In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.

AB - In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.

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U2 - 10.1016/S0022-3476(76)81073-6

DO - 10.1016/S0022-3476(76)81073-6

M3 - Article

C2 - 178851

AN - SCOPUS:0017101238

VL - 88

SP - 1041

EP - 1043

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 6

ER -

25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia

Abstract

ASJC Scopus subject areas

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