TY - JOUR
T1 - 2016 updated MASCC/ESMO consensus recommendations
T2 - Prevention of nausea and vomiting following moderately emetogenic chemotherapy
AU - Roila, Fausto
AU - Warr, David
AU - Hesketh, Paul J.
AU - Gralla, Richard
AU - Herrstedt, Jorn
AU - Jordan, Karin
AU - Aapro, Matti
AU - Ballatori, Enzo
AU - Rapoport, Bernardo
N1 - Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Purpose: An update of the recommendations for the prophylaxis of acute and delayed emesis induced by moderately emetogenic chemotherapy published after the last MASCC/ESMO antiemetic consensus conference in 2009 has been carried out. Methods: A systematic literature search using PubMed from January 1, 2009 to January 6, 2015 with a restriction to papers in English was conducted. Results: Overall, two randomized phase II and seven randomized phase III studies plus the results of three subgroup analysis of large phase III trials and those of a pilot study have been included. Conclusions: In carboplatin-treated patients, a moderate benefit from adding an NK1 receptor antagonist to dexamethasone and a 5-HT3 receptor antagonist has been shown. However, in oxaliplatin-treated patients, contrasting results about the role of NK1 receptor antagonists have been obtained. At present, it is not possible to suggest a specific 5-HT3 receptor antagonist to use for the prevention of acute emesis in these patients. No routine prophylaxis for delayed emesis is recommended but in patients receiving moderately emetogenic chemotherapy with known potential for delayed emesis (e.g., oxaliplatin, doxorubicin, cyclophosphamide) the use of dexamethasone for days 2–3 can be considered.
AB - Purpose: An update of the recommendations for the prophylaxis of acute and delayed emesis induced by moderately emetogenic chemotherapy published after the last MASCC/ESMO antiemetic consensus conference in 2009 has been carried out. Methods: A systematic literature search using PubMed from January 1, 2009 to January 6, 2015 with a restriction to papers in English was conducted. Results: Overall, two randomized phase II and seven randomized phase III studies plus the results of three subgroup analysis of large phase III trials and those of a pilot study have been included. Conclusions: In carboplatin-treated patients, a moderate benefit from adding an NK1 receptor antagonist to dexamethasone and a 5-HT3 receptor antagonist has been shown. However, in oxaliplatin-treated patients, contrasting results about the role of NK1 receptor antagonists have been obtained. At present, it is not possible to suggest a specific 5-HT3 receptor antagonist to use for the prevention of acute emesis in these patients. No routine prophylaxis for delayed emesis is recommended but in patients receiving moderately emetogenic chemotherapy with known potential for delayed emesis (e.g., oxaliplatin, doxorubicin, cyclophosphamide) the use of dexamethasone for days 2–3 can be considered.
KW - 5-HT3 receptor antagonists
KW - Carboplatin
KW - Irinotecan
KW - Moderately emetogenic chemotherapy
KW - NK1 receptor antagonists
KW - Oxaliplatin
UR - http://www.scopus.com/inward/record.url?scp=84981170540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981170540&partnerID=8YFLogxK
U2 - 10.1007/s00520-016-3365-1
DO - 10.1007/s00520-016-3365-1
M3 - Article
C2 - 27510316
AN - SCOPUS:84981170540
SN - 0941-4355
VL - 25
SP - 289
EP - 294
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 1
ER -