2016 updated MASCC/ESMO consensus recommendations: Prevention of nausea and vomiting following moderately emetogenic chemotherapy

Fausto Roila, David Warr, Paul J. Hesketh, Richard J. Gralla, Jorn Herrstedt, Karin Jordan, Matti Aapro, Enzo Ballatori, Bernardo Rapoport

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Purpose: An update of the recommendations for the prophylaxis of acute and delayed emesis induced by moderately emetogenic chemotherapy published after the last MASCC/ESMO antiemetic consensus conference in 2009 has been carried out. Methods: A systematic literature search using PubMed from January 1, 2009 to January 6, 2015 with a restriction to papers in English was conducted. Results: Overall, two randomized phase II and seven randomized phase III studies plus the results of three subgroup analysis of large phase III trials and those of a pilot study have been included. Conclusions: In carboplatin-treated patients, a moderate benefit from adding an NK1 receptor antagonist to dexamethasone and a 5-HT3 receptor antagonist has been shown. However, in oxaliplatin-treated patients, contrasting results about the role of NK1 receptor antagonists have been obtained. At present, it is not possible to suggest a specific 5-HT3 receptor antagonist to use for the prevention of acute emesis in these patients. No routine prophylaxis for delayed emesis is recommended but in patients receiving moderately emetogenic chemotherapy with known potential for delayed emesis (e.g., oxaliplatin, doxorubicin, cyclophosphamide) the use of dexamethasone for days 2–3 can be considered.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalSupportive Care in Cancer
DOIs
StateAccepted/In press - Aug 11 2016

    Fingerprint

Keywords

  • 5-HT3 receptor antagonists
  • Carboplatin
  • Irinotecan
  • Moderately emetogenic chemotherapy
  • NK1 receptor antagonists
  • Oxaliplatin

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology

Cite this

Roila, F., Warr, D., Hesketh, P. J., Gralla, R. J., Herrstedt, J., Jordan, K., Aapro, M., Ballatori, E., & Rapoport, B. (Accepted/In press). 2016 updated MASCC/ESMO consensus recommendations: Prevention of nausea and vomiting following moderately emetogenic chemotherapy. Supportive Care in Cancer, 1-6. https://doi.org/10.1007/s00520-016-3365-1