κ Opioid receptor-mediated analgesia in the developing rat

Gordon A. Barr, William Paredes, Karen L. Erickson, R. Suzanne Zukin

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The prototypic κ opiate ketocyclazocine produced robust analgesia in 10-day-old rats in the tail-flick nociceptive test. The κ-opiate behavioral response coincided with the onset of a rapid rise to adult levels in brain κ receptor site density. In contrast, morphine (prototypic μ opiate) was without marked effect until 14 days of age. The period of rapid μ receptor increase did not take place until days 14-16, which was after κ receptor levels had already plateaued. Further, there was no or incomplete cross-tolerance between ketocyclazocine and morphine at 14 days of age. The present study, therefore, establishes a role for the κ binding site in thermal analgesia in the tail flick test and differentiates its ontogenetic pattern from that of the μ receptor.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalDevelopmental Brain Research
Volume29
Issue number2
DOIs
StatePublished - Oct 1986

Keywords

  • development
  • ontogeny
  • opiate-induced analgesia
  • tolerance
  • κ opioid receptor
  • μ opioid receptor

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Fingerprint Dive into the research topics of 'κ Opioid receptor-mediated analgesia in the developing rat'. Together they form a unique fingerprint.

  • Cite this