κ Opioid receptor-mediated analgesia in the developing rat

Gordon A. Barr, William Paredes, Karen L. Erickson, R. Suzanne Zukin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The prototypic κ opiate ketocyclazocine produced robust analgesia in 10-day-old rats in the tail-flick nociceptive test. The κ-opiate behavioral response coincided with the onset of a rapid rise to adult levels in brain κ receptor site density. In contrast, morphine (prototypic μ opiate) was without marked effect until 14 days of age. The period of rapid μ receptor increase did not take place until days 14-16, which was after κ receptor levels had already plateaued. Further, there was no or incomplete cross-tolerance between ketocyclazocine and morphine at 14 days of age. The present study, therefore, establishes a role for the κ binding site in thermal analgesia in the tail flick test and differentiates its ontogenetic pattern from that of the μ receptor.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalDevelopmental Brain Research
Volume29
Issue number2
DOIs
StatePublished - 1986

Fingerprint

Opiate Alkaloids
Opioid Receptors
Analgesia
Morphine
Tail
Hot Temperature
Binding Sites
Brain
ketazocine

Keywords

  • development
  • ontogeny
  • opiate-induced analgesia
  • tolerance
  • κ opioid receptor
  • μ opioid receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

κ Opioid receptor-mediated analgesia in the developing rat. / Barr, Gordon A.; Paredes, William; Erickson, Karen L.; Zukin, R. Suzanne.

In: Developmental Brain Research, Vol. 29, No. 2, 1986, p. 145-152.

Research output: Contribution to journalArticle

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