β-Adrenergic blockade is more effective in suppressing adrenaline-induced glucose production in Type 1 (insulin-dependent) diabetes

Harry Shamoon, R. Sherwin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To examine whether diabetes affects the ability of β-blockade to suppress adrenaline-stimulated hepatic glucose production, we infused adrenaline with and without propranolol into normal subjects and diabetic patients receiving a constant insulin infusion in basal amounts. In normal subjects, propranolol did not block the transient 50%-60% rise in glucose production during adrenaline infusion. In contrast, propranolol virtually abolished adrenaline-induced hyperglycaemia and glucose production was virtually abolished by propranolol in the diabetic patients, even though they demonstrated an exaggerated response to adrenaline alone (persistent increase in glucose production of 50%-90% above baseline). When insulin was infused together with adrenaline and propranolol in normal subjects in doses exceeding those given to the diabetics (plasma insulin rose threefold), the rise in glucose production was still threefold greater than in the diabetic patients (p<0.02). We conclude that β-blockade is more effective in suppressing the hepatic response to adrenaline in diabetics than in normal subjects. Our data may explain why diabetic subjects are more vulnerable to hypoglycaemia during treatment with propranolol.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalDiabetologia
Volume26
Issue number3
DOIs
StatePublished - Mar 1984

Fingerprint

Adrenergic Agents
Epinephrine
Propranolol
Insulin
Glucose
Liver
Hypoglycemia
Hyperglycemia

Keywords

  • β-blockade
  • adrenaline
  • catecholamine action
  • diabetes mellitus
  • glucose kinetics
  • liver
  • propranolol

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

β-Adrenergic blockade is more effective in suppressing adrenaline-induced glucose production in Type 1 (insulin-dependent) diabetes. / Shamoon, Harry; Sherwin, R.

In: Diabetologia, Vol. 26, No. 3, 03.1984, p. 183-189.

Research output: Contribution to journalArticle

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