α2-MACROGLOBULIN AND REDUCED BASEMENT-MEMBRANE DEGRADATION IN DIABETES

Michael Brownlee

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Thickening of the capillary basement membrane is the fundamental morphological alteration of diabetic microangiopathy. Leucocyte neutral proteases can degrade basement membrane in vivo. The activity of a purified neutral protease from granulocytes is inhibited by α2-macroglobulin. It is suggested that the reported increase in the concentration of α2-macroglobulin in the blood of diabetic patients inhibits the activity of leucocyte neutral proteases which normally degrade basement membrane. The resultant decreased rate of breakdown would contribute to the increase in basement-membrane material seen in diabetes.

Original languageEnglish (US)
Pages (from-to)779-780
Number of pages2
JournalThe Lancet
Volume307
Issue number7963
DOIs
Publication statusPublished - Apr 10 1976

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ASJC Scopus subject areas

  • Medicine(all)

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