TY - JOUR
T1 - γ Chain-associated cytokine receptors signal through distinct transducing factors
AU - Pernis, Alessandra
AU - Gupta, Sanjay
AU - Yopp, James
AU - Garfein, Evan
AU - Kashleva, Helena
AU - Schindleri, Chris
AU - Rothman, Paul
PY - 1995/6/16
Y1 - 1995/6/16
N2 - The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
AB - The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand- specific binding chains that associate with a shared signaling subunit, the common γ (γ(c)) chain. In addition, IL-2, IL-4, and IL-7 induce activation of a common set of nonreceptor tyrosine kinases, Jak-1 and Jak-3. We have further investigated the signaling events induced by these cytokines and find that the γ(c)-associated receptors activate distinct signal transducing factors (STFs). In addition, we show that a 94-kDa STAT-related protein (p94) is activated in response to IL-2 and IL-7, but not IL-4. These data indicate that IL-2, IL-4, and IL-7 activate distinct signaling molecules which might be differentially recruited to the receptor complex by the ligand-specific units of the IL-2, IL-4, and IL-7 receptors.
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U2 - 10.1074/jbc.270.24.14517
DO - 10.1074/jbc.270.24.14517
M3 - Article
C2 - 7782314
AN - SCOPUS:0029031756
SN - 0021-9258
VL - 270
SP - 14517
EP - 14522
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 24
ER -