Project: Research project

Project Details


DESCRIPTION (Adapted from Applicant's Abstract): Magnetic Resonance Imaging
(MRI) techniques, are rapidly being developed to allow for the quantitative
assessment of cerebral blood flow (CBF) in both experimental animals and
man. These MRI-based methods offer many advantages over other techniques
like inert Xe131-CT, or H2O15 PET, because they are non-invasive and can be
acquired registered to high resolution anatomical, functional, and
spectroscopic images of cerebral metabolism. These new MRI-based methods of
perfusion assessment are based upon the arterial spin labeling technique
first introduced by Williams et. al. and include EPISTAR, FAIR, UNFAIR and
QUIPPS. These techniques are just beginning to be applied in the clinical
setting, and although they are very promising, there is a need to validate
these methods and to examine the sources of error in their use. The
applicants proposed to systematically investigate the sources of error of
these techniques including estimates of transit times and partition
coefficients, arterial relaxation times and magnetization transfer effects.
They would also compare the estimates of cerebral perfusion obtained with
these MR-based techniques with the well established technique of CBF
measurement using intracardiac bolus injection of labeled microspheres.
These studies would be conducted in nonpathologic normally perfused brain,
and under ischemic conditions using middle cerebral artery occlusion in
rats. This work could improve the reliability of MRI based measurements of
cerebral perfusion and would, therefore, provide for their routine
application in clinical and research settings.
Effective start/end date5/1/983/31/03


  • Radiology Nuclear Medicine and imaging


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