The Pathogenic Role of Interneurons in Huntington's Disease

Project: Research project

Project Details


The proposed research is relevant to the public health because it interrogates the mechanisms underlying neural
developmental deficits with key pathogenic roles in Huntington’s disease. More specifically, it will define what
processes adversely influence the elaboration of interneurons, how their reductions impact the maturation of
relevant brain circuits, and whether these deficits yield neuronal species more susceptible to stressors.
Accordingly, this research would uncover mechanistic cascades that will provide the substrate for the
development of therapeutic paradigms aimed at modifying disease progression, which is relevant to the goals of
NIH’s overall strategic mission.
Effective start/end date12/1/2011/30/22


  • National Institute of Neurological Disorders and Stroke: $560,289.00
  • National Institute of Neurological Disorders and Stroke: $623,619.00


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