Narrative: The proposed research is relevant to the public health because it interrogates the mechanisms underlying neural developmental deficits with key pathogenic roles in Huntington’s disease. More specifically, it will define what processes adversely influence the elaboration of interneurons, how their reductions impact the maturation of relevant brain circuits, and whether these deficits yield neuronal species more susceptible to stressors. Accordingly, this research would uncover mechanistic cascades that will provide the substrate for the development of therapeutic paradigms aimed at modifying disease progression, which is relevant to the goals of NIH’s overall strategic mission.
|Effective start/end date||12/1/20 → 11/30/22|
- National Institute of Neurological Disorders and Stroke: $560,289.00
- National Institute of Neurological Disorders and Stroke: $623,619.00
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