Project Details
Description
HIV may be associated with premature aging in the female genital tract including alterations in the vaginal
microbiome and mucosal inflammation, which may increase risk for vaginal atrophy, UTIs and other genital
tract infections. This study will determine if HIV is associated with accelerated genital tract aging including
earlier and more pronounced changes in the vaginal microbiome and mucosal inflammation in menopausal
women living with HIV (WLWH) compared to HIV uninfected menopausal women. We will then test whether
vaginal estradiol will improve symptoms and the vaginal microbiome and reduce mucosal inflammation in
menopausal WLWH with vaginal atrophy, thereby improving vaginal health and healthspan.
Status | Active |
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Effective start/end date | 2/1/20 → 1/31/23 |
Funding
- National Institute on Aging: $395,280.00
- National Institute on Aging: $197,640.00
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