TB Phage therapy: Optimizing delivery methods of mycobacteriophages to target intracellular Mycobacterium tuberculosis

Project: Research project

Project Details

Description

Project Narrative
Tuberculosis (TB) remains a global health problem resulting in 1.2 million deaths and 10 million new cases per
year. Although drugs exist to cure TB, short course chemotherapy is a minimum six-month regimen.
Mycobacterium tuberculosis (the causative agent of TB) strains have developed resistance to all TB drugs and
novel therapies are urgently needed. Previous studies have found mycobacteriophages can kill M. tuberculosis
suggesting that these organisms could prove to be an invaluable resource to fight this global epidemic The
goal of this proposal is to develop strategies to use these mycobacteriophages to shorten chemotherapy and
kill drug resistant forms of M. tuberculosis.
StatusActive
Effective start/end date12/7/2011/30/22

Funding

  • National Institute of Allergy and Infectious Diseases: $210,000.00
  • National Institute of Allergy and Infectious Diseases: $251,938.00

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