STRUCTURE, SECRETION AND MECHANISM OF ACTION OF PARATHYROID HORMONE

Project: Research project

Project Details

Description

It is the purpose of this project to study the secretion, function, and
mechanism of action of parathyroid hormone, its relationship to human
disease, and to develop clinically useful tests for circulating
parathyroid hormone. From these studies it is expected that one can
understand the pathophysiology of certain metabolic diseases of bone and
endocrine disturbances. The entire structures of bovine, porcine, rat
and human parathyroid hormone have been determined. Synthetic
polypeptides representing bovine rat and human parathyroid hormone have
been synthesized. These molecules shows all the biological properties
of the native hormonal polypeptides. Highly sensitive radioimmunoassays
for the hormone have been developed and are being modified further for
improved clinical diagnostic parameters. Studies show that the mechanism
of action of the hormone is mediated through direct hormonal activation
of adenylate cyclase in bone and kidney. Isolated parathyroid cells and
culture systems have been developed that allow studies on secretory
control of parathyroid hormone, and provide test systems to elucidate the
pathophysiology of certain hypoparathyroid and hyperparathyroid states.
StatusNot started

ASJC

  • Pathophysiology